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Panuch Eiamprapaporn

As seen in: Nature
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Articles

Validation of pathology-based triage for the 21-gene recurrence score: a meta-analysis and qualitative synthesis of the Magee equations

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By Thiti Susiriwatananont, Panuch Eiamprapaporn, Yaohua Ma, Phuwanat Sakornsakolpat, Yi Liu, E. Aubrey Thompson, Saranya Chumsri, Jirawat Thanestada
| Nature Verified
Abstract The 21-gene Oncotype DX (ODX) recurrence score (RS) is the standard for HR + /HER2- early breast cancer risk stratification, but prohibitive costs limit global accessibility. This meta-analysis of 13 studies (N = 5396) validates the Magee Equations (ME)—utilizing routine pathology (grade, ER/PR/HER2/Ki-67)—as a safe triage tool. For the TAILORx threshold (RS 26 or higher), a ME <18 yielded a pooled negative predictive value (NPV) of 0.96 (95% CI: 0.94–0.97) and a 62% test-sparing rate.
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The Gut Microbiome as a Biomarker and Therapeutic Target of Immune Checkpoint Inhibitors: A Review for Oncologists

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By Thiti Susiriwatananont, Maria Vazquez-Roque, Francis A. Farraye, Panuch Eiamprapaporn
| preprints.org
Submitted: 19 October 2025 You are already at the latest version Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, yet their benefits remain limited to a subset of patients, underscoring the need for more reliable biomarkers and novel therapeutic strategies. The gut microbiome has emerged as a critical modulator of systemic immunity and a promising determinant of ICI response.
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