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Pascal Miéville

As seen in: Nature, Cell Press, Chemistry World
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Articles by Pascal Miéville

High-throughput solid microsampling through stochastic robotic automation

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By Adam Lisowski, Alec Schmidt, Ashley Stark, Florian De Nanteuil, Mathias Cherbuin, Pascal Miéville, Keyan Villat, Edy Mariano, Jean-Charles Cousty, Jérôme Guérin, Frédéric Vasserot, Achim Ammon, David Gueller, Jean-Jacques Schwartz, Marc Kunze, Giuseppe Costanzo
| Nature Verified
Abstract Solid sampling at the sub-milligram and milligram scale remains a major bottleneck for high-throughput chemistry or material sciences, as existing approaches rely on manual handling or slow deterministic microsampling that do not readily scale. Here we present STORMS, an automated STOchastic Robotic MicroSampling system that enables fast, reliable and parallel sampling of solid materials at sub-milligram and milligram masses.
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Photochromic Torsional Switch (PTS): a Light-Driven Actuator for the Dynamic Tuning of π-Conjugation Extension

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By Clemence Corminboeuf, Pascal Miéville, Giuseppe Sforazzini, Daniele Fazzi
| Chemistry World Verified
Here we present a molecular architecture that can reversibly change the geometric conformation of its π-system backbone via irradiation with two different wavelengths. The proposed ‘molecular actuator’ consists of a photoswitchable azobenzene orthogonally connected to a π-conjugated bithiophene by both direct and aliphatic linker-assisted bonding.
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Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling

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By Elizabeth Allen, Epfl Sv Isrec, Pascal Miéville, Carmen M. Warren, Sadegh Saghafinia
| Cell Press Verified
AI Treatment of Mouse PanNETs Produces Upregulation of Glucose and Lactate Transporters in Patterns Suggestive of Metabolic Symbiosis Mouse PanNET Tumors and Cell Lines Consume and Catabolize Lactate to Establish Metabolic Symbiosis mTOR Signaling in Cultured Cancer Cells can Be Upregulated by Lactate and Glutamine Metabolism The combination of rapamycin plus sunitinib treatment for 1–2 weeks reproducibly elicited tumor regression, characterized by widespread necrosis and fibrosis, and...
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