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Patcharee Ritprajak on Muck Rack

Patcharee Ritprajak

As seen in: The Journal of Biological Chemistry
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Articles

Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction

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By Morisada Hayakawa, Hiroko Hayakawa, Tsvetana Petrova, Patcharee Ritprajak
| The Journal of Biological Chemistry Verified
The evolutionarily conserved protein kinase p38 mediates innate resistance to environmental stress and microbial infection. Four p38 isoforms exist in mammals and may have been co-opted for new roles in adaptive immunity. Murine T cells deficient in p38?, the ubiquitously expressed p38 isoform, showed no readily apparent cell-autonomous defects while expressing elevated amounts of another isoform, p38?. Mice with T cells simultaneously lacking p38? and p38?
Open in Who Shared Issue with article?

Loss of functionally redundant p38 isoforms in T cells enhances regulatory T cell induction

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By Morisada Hayakawa, Hiroko Hayakawa, Tsvetana Petrova, Patcharee Ritprajak
| The Journal of Biological Chemistry Verified
Author contributions: MH, KO, KG, JSCA, and JMP designed the study and wrote the paper. MH, HH, TP, PR, RVS, GYJ-A, YS, M-KC, JS, RKCV, and JMP generated and analyzed p38 and MK KO mice. MH, TP, PR, RVS, RKCV, and JMP performed in vitro experiments. MH, PR, KO, KG, JSCA, and JMP interpreted data. All authors reviewed the results and approved the final version of the manuscript. The evolutionarily conserved protein kinase p38 mediates innate resistance to environmental stress and microbial infection.
Open in Who Shared Issue with article?
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