Articles by Patrick Chang
Sa1841 ASSOCIATION OF SEX WITH ACUTE PANCREATITIS OUTCOMES: A PROPENSITY-MATCHED ANALYSIS
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Response:
We read with interest the commentary by Yu1 on our study showing benefits of AI-assisted colonoscopy in an Accreditation Council for Graduate Medical Examination (ACGME)-accredited Gastroenterology Fellowship training program.2 Given increasing integration of artificial intelligence (AI), we value his appreciation that we approach a critical evolution of endoscopic training that requires several concerns to be explicitly addressed.
Impact of artificial intelligence–assisted colonoscopy on gastroenterology fellow performance: a pragmatic randomized controlled trial
Abbreviations ACGME (Accreditation Council for Graduate Medical Education) ADR (adenoma detection rate) AI (artificial intelligence) CADe (computer-aided detection) CC (conventional colonoscopy) CRC (colorectal cancer) GE (gastrointestinal) LADR (left-sided colon adenoma detection rate) PDR (polyp detection rate) PGY (postgraduate year) Procedure (time from colonoscope insertion to withdrawal of colonoscopy) RADR (right-sided colon adenoma detection rate) Withdrawal (time from cecum to...
Disparidades geográficas y socioeconómicas en los trastornos por consumo de sustancias y opioides
Me Gusta 1 1 Comentar 2 2 Autor/autores: Jin S. Kim, Patrick W. Chang, Jason Hung...(et.al) Fecha de publicación: 01/08/2025 Artículo | Artículo revisado por nuestra redacción Objetivo El trastorno por consumo de sustancias (SUD) es un problema de salud pública significativo que puede coexistir con diversas enfermedades crónicas, incluida la enfermedad inflamatoria intestinal (EII). Sin embargo, la relación entre la EII y el SUD sigue sin estar completamente caracterizada.
Recalibrate with agility
TWENTY twenty-four brought surprises, with equities outperforming fixed income for a second year despite slowing inflation, while gold thrived on central bank purchases and geopolitical risks. Post-US elections, markets embraced the “Trump trade” – or, as we prefer to call it, Trump 2.0. Already a subscriber? Log in. Get 30% off with our ads free Premium Plan! Billed as RM9.73 for the 1st month then RM13.90 thereafters.
Stage-specific CAR-mediated signaling generates naive-like, TCR-null CAR T cells from induced pluripotent stem cells
Abstract Genetically modified, induced pluripotent stem cells (iPSCs) offer a promising allogeneic source for the generation of functionally enhanced, chimeric antigen receptor (CAR) T cells.
Medical, Endoscopic, and Surgical Management of Gastroesophageal Reflux Disease
Introduction Gastroesophageal reflux disease (GERD) is a frequently encountered condition, and rising annually.1 A recent meta-analysis suggests nearly 14% (1.03 billion) of the population are affected worldwide.
Author Correction: Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells - Nature
Correction to: Nature https://doi.org/10.1038/s41586-024-07121-9 Published online 28 February 2024 In the version of the article initially published, the Data availability section did not include the accession codes for the sequencing data generated in this study (available from the Gene Expression Omnibus (GEO) repository under accession code GSE260816) and the clinical study data (available from the European Genome-Phenome Archive (EGA) under the accession code EGAS50000000251).
Publisher Correction: Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells - Nature
Correction to: Nature https://doi.org/10.1038/s41586-024-07121-9 Published online 28 February 2024 This article was originally published under standard Springer Nature License (© The Author(s), under exclusive licence to Springer Nature Limited). It is now available as an open-access paper under a Creative Commons Attribution 4.0 International license, © The Author(s). The error has been corrected in the HTML and PDF versions of the article.
Publisher Correction: Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells - Nature
Correction to: Nature https://doi.org/10.1038/s41586-024-07121-9 Published online 28 February 2024 In the initially published version of the article, the x-axis labels in Figs. 4b–d and 6a and c mistakenly included a minus sign and have now been corrected to “log2[FC]”. Additionally, the footnote denoting authors’ equal contributions was removed. These corrections have been made to the HTML and PDF versions of the article. About this article Guan, X., Hu, R., Choi, Y. et al.
Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells - Nature
Abstract Tiragolumab, an anti-TIGIT antibody with an active IgG1κ Fc, demonstrated improved outcomes in the phase 2 CITYSCAPE trial (ClinicalTrials.gov: NCT03563716) when combined with atezolizumab (anti-PD-L1) versus atezolizumab alone1. However, there remains little consensus on the mechanism(s) of response with this combination2.
Foraminal stenosis and radiculopathy secondary to tophaceous gout: illustrative case
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THE USE OF OVERLAPPING COVERED METAL STENTS TO MANAGE ACUTE CHOLANGITIS AND HEMOBILIA IN THE SETTING OF ARTERIO-BILIARY FISTULA CAUSED BY ERODING EMBOLIZATION COILS
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INCREASED MORTALITY IS ASSOCIATED WITH RISING ANTIBIOTIC RESISTANT INFECTIONS DURING INPATIENT ENDOSCOPIC RETROGRADE CHOLANGIOGRAPHY (ERCP)
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INCREASED MORTALITY IS ASSOCIATED WITH RISING ANTIBIOTIC RESISTANT INFECTIONS DURING INPATIENT ENDOSCOPIC RETROGRADE CHOLANGIOGRAPHY (ERCP)
Cookie Preference Center We use cookies which are necessary to make our site work. We may also use additional cookies to analyse, improve and personalise our content and your digital experience. For more information, see our Cookie Policy and the list of Google Ad-Tech Vendors. You may choose not to allow some types of cookies. However, blocking some types may impact your experience of our site and the services we are able to offer.
INCREASED MORTALITY IS ASSOCIATED WITH RISING ANTIBIOTIC RESISTANT INFECTIONS DURING INPATIENT ENDOSCOPIC RETROGRADE CHOLANGIOGRAPHY (ERCP)
Cookie Preference Center We use cookies which are necessary to make our site work. We may also use additional cookies to analyse, improve and personalise our content and your digital experience. For more information, see our Cookie Policy and the list of Google Ad-Tech Vendors. You may choose not to allow some types of cookies. However, blocking some types may impact your experience of our site and the services we are able to offer.
Human T cell generation is restored in CD3δ severe combined immunodeficiency through adenine base editing
Garcillán B. Fuentes P. Marin A.V.v. Megino R.F. Chacon-Arguedas D. Mazariegos M.S. Jiménez-Reinoso A. Muñoz-Ruiz M. Laborda R.G. Cárdenas P.P. et al. CD3G or CD3D knockdown in mature, but not immature, T lymphocytes similarly cripples the human TCRαβ complex. Front. Cell Dev. Biol. 2021; 9: 608490https://doi.org/10.3389/fcell.2021.608490 Dadi H.K. Simon A.J. Roifman C.M. Effect of CD3 d deficiency on maturation of a/b and g/d T-cell lineages in severe combined immunodeficiency. N. Engl. J. Med.
Association of Standardized Radiology Reporting and Management of Abdominal CT and MRI With Diagnosis of Pancreatic Cancer
Background & Aims Follow-up of abdominal computed tomography (CT) and magnetic resonance imaging (MRI) findings suspicious for pancreatic cancer may be delayed if documentation is unclear. We evaluated whether standardized reporting and follow-up of imaging results reduced time to diagnosis of pancreatic cancer. Methods We used a quasi-experimental stepped-wedge cluster design to evaluate the effectiveness of newly implemented radiology reporting system.
Commentary: When and what to buy? At what age? Investing for retirement in a COVID-19 economy
SINGAPORE: For every Singaporean senior looking forward to saving enough to enjoy retirement, the COVID-19 pandemic has been a rude awakening. COVID-19 has upended entire industries and created uncertainty for many jobs. Advertisement Advertisement While Singapore’s economy is expected to recover by 4 to 6 per cent this year, there is an economist consensus growth will be gradual, uneven with little relief for sectors related to air travel.
Fourier instantaneous estimators and the Epps effect
Loading metrics Open Access Peer-reviewed Research Article Patrick Chang Published: September 22, 2020 https://doi.org/10.1371/journal.pone.0239415 Figures Abstract We compare the Malliavin-Mancino and Cuchiero-Teichmann Fourier instantaneous estimators to investigate the impact of the Epps effect arising from asynchrony in the instantaneous estimates. We demonstrate the instantaneous Epps effect under a simulation setting and provide a simple method to ameliorate the effect.
Complete Cloud Native Security Is Here
By Ron Harnik, senior product marketing manager, and Patrick Chang, senior director, product management Prisma Cloud extends to workload protection and vulnerability management with Twistlock and PureSec It’s a cliché at this point to open these blog posts with a line about how “enterprises are embracing the cloud.” Everybody knows that, and yes, I realize I just did it. Old habits die hard.
Commentary: Singapore’s bold bet on seniors and valuable years of life experience
SINGAPORE: Prime Minister Lee Hsien Loong has announced bold changes to raise the retirement and re-employment ages at the National Day Rally on Sunday (Aug 18). While the retirement age will be raised from age 62 to 63 in 2022, and 65 by 2030, the re-employment age will be raised from 67 to 68 in 2022, and 70 by 2030.
Commentary: Still paying off your housing loan at 65? Five rules to a happy retirement
SINGAPORE: Guess how many seniors are still paying off their housing loan? Hard to imagine isn’t it? Advertisement But according to a Credit Bureau Singapore study in 2014, the number of Singaporeans aged 65 and above still servicing outstanding mortgage loans numbered over 15,000 – triple the figure in 2008. It’s harder to imagine how these seniors will achieve retirement adequacy.
Why we invested in Dapper Labs
At Samsung NEXT, we believe the technology world is in the midst of a paradigm shift, one in which the world is rapidly moving from a world of centralized applications and services to those which are decentralized. Given the stage we’re at in that transformation, we believe the most value created today will be from advancements that come in the protocol and infrastructure layer of the blockchain world.
Commentary: Reasonable to expect S$3,000 a month for retirement
How much we need for our retirement depends on the lifestyle we aspire towards, says one financial consultant. SINGAPORE: Is wanting S$3,000 a month to spend in retirement excessive? After my commentary on retirement, some readers pointed out that this amount seemed high. But how much we need for a comfortable retirement depends on the kind of old age lifestyle we aspire towards.
Commentary: Saving too little, starting too late, do we have enough for retirement?
Many of us put off planning for our retirement until we’re in our forties but it doesn’t have to be an onerous chore, says one financial advisor. SINGAPORE: John Ng, aged 40, plans to retire at 65 with S$3,000 monthly to spend in real terms. He hopes to enjoy such an income in his old age for 20 years. By the time he retires, he must set aside a retirement sum of almost S$1.15 million, assuming a long-term inflation rate of 3 per cent. What can John do now?
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