Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Patrick Costello
The MRTFs are required for thymocyte trafficking and Treg-mediated immune tolerance
Abstract The MRTFs (myocardin-related transcription factors) are essential for effective cytoskeletal function during differentiation and development. To investigate the role played by the MRTFs in T cell development and function we inactivated Mrtfb in Mrtfa-null mice at the DN2 stage (MrtfabKOT animals). Positive selection, and development of MrtfabKOT regulatory (Treg), γδ, and NK Τ cells proceeded normally.
Labour’s New Foreign Policy?
Foreign Secretary Ed Miliband attending ASEAN conference (Credit: gov.uk) Foreign policy is clearly not the first priority of the Burnham government. The new PM did not refer to it in his acceptance speeches and in the early weeks, the only acknowledgement that the world outside the UK existed came in the form of a mea culpa on Palestine.
PAI Partners appoints Lazard to sell industrial insulation manufacturer Armacell
Buyout firm PAI Partners has engaged Lazard to guide a sale of portfolio company Armacell, three sources familiar with the matter said. PAI aims to launch an auction for the Luxembourg-headquartered insulation material manufacturer as early as this month or in October, the sources said. Armacell generates EBITDA of between EUR 160m-EUR 170m, according to two of the sources, with one of them noting these are the estimated figures for the financial year 2025.
Regulating The Promise, Not The Token: What Regulation Crypto Assets Would Change
Patrick Costello’s articles from Bevilacqua are most popular: within Finance and Banking topic(s) in United States with readers working within the Business & Consumer Services, Healthcare and Media & Information industries Bevilacqua are most popular: within Finance and Banking topic(s) The proposed Regulation Crypto Assets framework would build on existing investment contract principles under federal securities law and the Securities and Exchange Commission’s March 2026 interpretive...
The SEC’s 45th Annual Small Business Forum Report: A Deregulatory Roadmap Already In Motion
Patrick Costello’s articles from Bevilacqua are most popular: in United States with readers working within the Law Firm industries Key Takeaways The 45th Forum’s 16 recommendations read less like a wish list than a working roadmap: the Commission’s responses map, recommendation by recommendation, to proposed rules already open for comment, staff initiatives underway, and legislation that has passed the House.
SEC Proposes Regulation E-Delivery: Electronic Delivery Would Become The Default Under The Federal Securities Laws
Patrick Costello’s articles from Bevilacqua are most popular: in United States with readers working within the Law Firm industries On July 16, 2026, the Securities and Exchange Commission proposed Regulation E-Delivery, a new rule that would permit issuers, investment advisers, broker-dealers, and other market participants to deliver required regulatory information electronically to investors and other covered recipients as the default method of delivery without first obtaining the...
Europa y la guerra con Irán: de la descoordinación hacia la autonomía estratégica
IdiomacatalàDeutschEnglishespañoleuskarafrançaisgalegoitalianoportuguêsromână
Far right falters in Europe?
Marine Le Pen - Credit : Rémi Noyon / Flickr Commons For over a decade, the far right has been on the march. In Europe, a cursory look suggests that the marchers are about to storm the citadels. In France and Germany, the two historic “motors” of EU integration, far-right parties (Rassemblement National (RN) and AfD) are leading in the polls.
SEC Staff Says Rule 506(c) Tokenized Offerings May Use On-Chain Accredited Investor Attestations
B Bevilacqua More As a transactional law firm, our business lawyers work on behalf of various private and publicly held companies, tackling the most complex domestic and international business challenges. This level of proficiency allows our clients to benefit from seasoned and proactive legal guidance at every stage, no matter what issues arise.
Downfall of the Assad regime
Inevitably, there has been a flurry of new books on Syria published since the fall of the Assad regime in December 2024. These two, both planned and mostly written when the possibility of overthrowing Assad looked impossibly remote, are the best of the crop for those interested in understanding the nature of both the Assad regime and the evolving nature of the opposition to it. In different ways, both books offer something rare: an insider’s view communicated by outsiders.
Your Alma Mater As An Asset Class: Regulation A Tier 2 Offerings For University-Affiliated Athletics And NIL Platforms
B Bevilacqua More As a transactional law firm, our business lawyers work on behalf of various private and publicly held companies, tackling the most complex domestic and international business challenges. This level of proficiency allows our clients to benefit from seasoned and proactive legal guidance at every stage, no matter what issues arise.
Setting the world on fire
On 9 April, Pakistan had seemingly succeeded in brokering a temporary ceasefire to Trump and Netanyahu’s war of choice with Iran. As Europe’s leaders publicly welcomed the deal, Spain’s PM, Pedro Sanchez, issued a tweet aimed at both Trump and his fellow European leaders. “The government of Spain will not applaud those who set the world on fire just because they show up with a bucket”.
Reg CF Offerings That Cross April 30: Does The Required Financial Statement Update Trigger Investor Reconfirmation?
Patrick Costello’s articles from Bevilacqua are most popular: within Corporate/Commercial Law topic(s) in United States with readers working within the Banking & Credit, Healthcare and Technology industries Bevilacqua are most popular: within Corporate/Commercial Law topic(s) Every spring, capital markets counsel advising issuers in live Regulation Crowdfunding (“Reg CF”) offerings face a recurring question.
Patrick Costello (1958–2026) of Metamora, IL, IL | Obituary
Patrick Aaron Costello, 67, passed away Saturday April 25th, 2026 at his home. Born Nov. 13, 1958 in St. Louis, he was son to Joan (McDonald) Costello and Maurice Costello. Pat was preceded in death by both parents and sister, Marie Schroeder. He married the love of his life, Letha M. Allen, Feb 16, 1985 at the former St. Bernard’s Catholic Church in Wood River, IL, now Holy Angels Catholic Church.
A continuous tragedy — Chartist
As Professor Marc Lynch explicitly states, his book was written at a moment of rage about the indiscriminate slaughter of Palestinians in Gaza and the US insistence on backing that slaughter. But, unusually, at a time when so many are focusing on Trump’s exceptionalism, he uses his rage to argue that this has not been an exceptional moment, but the logical outcome of over three decades of consistent US policy in the region.
Enhanced dynamic risk stratification of smoldering multiple myeloma
|
Abstract Accurate prediction of risk of progression from smoldering multiple myeloma (SMM) to active multiple myeloma (MM) is paramount to individualized early therapeutic strategies with minimum risk of overtreatment. Current risk stratification models do not account for evolving biomarker trajectories.
By Floris Chabrun, Daniel Schwartz, Susanna Gentile, Elias K. Mai, Tulika Gupta, Jacqueline Perry, Thomas Hielscher, Sophia Schmidt Verified, Foteini Theodorakakou, Despina Fotiou, Nikolaos Kanellias, Esperanza Martín-Sánchez, Johannes M. Waldschmidt, Selina J Chavda, Louise Ainley, Loredana Pettine, Michael Timonian, Jean-Baptiste Alberge, Vidhi Patel, Patrick Costello, Jennifer Lamb, Maya Davis, Elizabeth O’Donnell, Omar Nadeem, Niccolo Bolli, Kwee Yong, K. Martin Kortüm, Hermann Einsele, Maria-Victoria Mateos, Shaji Kumar Verified, Jesus San-Miguel, Jesús F San-Miguel, Bruno Paiva, Efstathios Kastritis, Meletios A. Dimopoulos, Marc S. Raab, Lorenzo Trippa, Irene M. Ghobrial, Annika Werly, Christine Ivy Liacos, Noelia Collado Gisbert, Rosalinda Termini, Claudio De Magistris, Catherine Tobia, Sally Phan, Maria-Theresa Silverio
|
Nature
Verified
The Price of Access to the US market
170 Share For much of the post–Cold War era, access to the American market was treated by European firms as a structural constant – vast, rules-based, and largely insulated from political turbulence. Companies competed on price, quality, branding, and logistics, confident that Washington might grumble about trade imbalances but would ultimately defend an open commercial order. That assumption has quietly expired.
Apps, SaaS Platforms, And Podcasts: Leveraging Owned Audiences To Raise Capital Under Regulation A Regulation D, And Regulation Crowdfunding
Patrick Costello’s articles from Bevilacqua are most popular: in United States Bevilacqua are most popular: within Corporate/Commercial Law topic(s) with readers working within the Banking & Credit, Oil & Gas and Retail & Leisure industries In today's digital economy, an engaged user or subscriber base is more than a marketing asset-it can be a compliant, scalable channel for raising capital.
Can A Private U.S. Company Access The European Capital Markets?
Patrick Costello’s articles from Bevilacqua are most popular: in United States Bevilacqua are most popular: within Corporate/Commercial Law topic(s) with readers working within the Banking & Credit, Oil & Gas and Retail & Leisure industries As U.S. companies look to expand their reach and growth prospects, Europe presents a lucrative market.
Far right firewall shattered — Chartist Original
Ursula von der Leyen - Credit: Dirk Vorderstraße/Flickr On 9th December, a deal was reached by EU ministers that cuts environmental reporting obligations for over 80% of Europe’s companies. In itself, it is bad enough; it looks much worse when zooming in on how this legislative sausage was made. In February, the von der Leyen (VDL) Commission launched the first of a series of so-called ‘omnibus’ proposals.
US National Insecurity! — Chartist Original
Democratic Socialist Futures Donald Trump is upending the world order that has existed since the end of the Second World War. This critique of the US administration’s National Security Strategy and Defence policy is the first of a series of long reads intended to stimulate deeper discussion on key policy issues and challenges facing the left today. We urge readers to respond on the website or to print Chartist.
Political lessons from France — Chartist Original
Possibly the biggest irony of Emmanuel Macron’s political career is that he entered politics to counter the far right. Jean-Marie Le Pen, Marine’s father, had reached the second round of the 2002 Presidential elections and was only beaten by left-wing voters holding their nose and voting for Jacques Chirac, the corrupt mayor of Paris.
Gaza - Europe’s last chance to act — Chartist Original
Often, it is harrowing photos that change policy by forcing a sea change in public opinion that governments cannot resist. Think of the 2015 photo of the dead Syrian child, Alan Kurdi, lying on the beach in Greece and how the reaction persuaded Angela Merkel to decide to allow Syrian refugees to enter Germany en masse. Think of the way in which the 1968 photo of the naked children being shot in the back by US GIs transformed US policies in Vietnam.
Bibi’s last gamble? — Chartist Original
Israel’s latest illegal military action, against Iran, is perhaps the most dangerous yet for global security. For two decades, Western military planners have successfully neutralised the efforts of anyone looking to take on the Islamic Republic directly, starting with John Bolton and the cast of US neocons who wanted to invade Iran from Iraq in 2004.
Regulation A+ Offerings: Mechanics, Market Data, And Capital Raising Best Practices For Startups And Emerging Companies
B Bevilacqua More As a transactional law firm, our business lawyers work on behalf of various private and publicly held companies, tackling the most complex domestic and international business challenges. This level of proficiency allows our clients to benefit from seasoned and proactive legal guidance at every stage, no matter what issues arise.
Patrick Costello "YOU CAN'T ASK THE WIND NOT TO BLOW"
NEWS - Patrick Costello "YOU CAN'T ASK THE WIND NOT TO BLOW" Passionate, gorgeous song of love and sorrow, all acoustic, featuring the dobro, fiddle, mandolin and bass. MIKE WITCHER ON DOBRO, ARI RIOS CO-PRODUCTION, CO-ARRANGMENT, AND BACKGROUND VOCALS, PAT COSTELLO, MUSIC AND LYRICS, PRODUCTION AND ARRANGEMENT, LEAD VOCALS https://knabokovcollective.bandcamp.com/track/you-cant-ask-the-wind-not-...
Tentative hope for Syria — Chartist
The dramatic collapse of Assad’s Syria caught the international community flat-footed. In the region, the Arab League had welcomed Assad back into their ranks only a year earlier as Arab embassies began to be reopened in Damascus.
Portents from Austria — Chartist
The clear win by Austria’s far right FPÖ in national elections on 30 September was further confirmation of far right normalisation across Europe. As in the Netherlands earlier this year, the “win” was nowhere near a majority (29%) but Austria’s conservatives have shown no inclination to shut the far right out of power in this election or in previous ones. The most likely outcome is a coalition driven by the FPÖ, whoever becomes the new chancellor.
IL-2 delivery to CD8+ T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics - Nature Communications
Abstract Paracrine IL-2 signalling drives the CD8 + T cell expansion and differentiation that allow protection against viral infections, but the underlying molecular events are incompletely understood. Here we show that the transcription factor SRF, a master regulator of cytoskeletal gene expression, is required for effective IL-2 signalling during L. monocytogenes infection.
Portugal and the fourth way — Chartist
Portugal’s 10 March elections dealt a heavy blow to the hopes of the European left. It wasn’t just that the Socialists and their allies lost so heavily, after an unprecedentedly successful eight years in power. These elections also marked an ominous breakthrough of the far right Chega party which jumped from one seat in 2019 to 50 out of 230, the third biggest party. For the pro-European left, Portugal’s last decade of government had been a model.
Doomsday Scenario in Europe — Chartist
The surprising result for Geert Wilders’ PVV in the Dutch national elections at the end of last year prompted a flurry of alarm in the UK press on the growing threat of the far right in Europe. These concerns have been heightened by polling earlier this year suggesting that the AfD in Germany is the second biggest party at 22% and that Marine Le Pen’s Rassemblement National (RN) is consistently in first place with up to a third of the French electorate’s support.
DACH advisors with access to US investors gain edge with tech deals – Advisory Viewer - ION Analytics
Technology companies with research and development (R&D) prowess remain an abundant source of mandates in Germany, Austria and Switzerland (DACH), with US investors driving much of the subsequent deal activity. This gives advisors who can offer clients access to a US investor base a leg up on the competition when looking to land sellside mandates in the tech space, said Andreas Kinsky, partner at Pava in Munich.
SEC Adopts Final Rules Enhancing Disclosures and Providing Additional Investor Protections Related to SPACs | JD Supra
Introduction Nearly two years after first proposing new rules related to special purpose acquisition companies (SPACs), the U.S. Securities and Exchange Commission (SEC) has adopted final rules aimed at enhancing investor protections in initial public offerings by SPACs and in subsequent de-SPAC transactions. The final rules require new enhanced disclosure requirements related to SPACs, and include new procedural protections in de-SPAC transactions.
Divisions and Dilemmas over Gaza — Chartist
While readers of the British press may be given a different impression, the eruption of violence in Israel and Palestine has not only been a source of division and controversy in the Labour Party: EU policymakers have also struggled to maintain a united front. Historically, Europe has played an important role in the international efforts to broker peace in the Middle East.
Westbridge Advisory sponsor GENUI preps ESG real estate specialist for 2024 sale, Lazard advises
Westbridge, a German property-sector services provider, is being prepped for sale by owner GENUI, three sources familiar with the situation told Mergermarket. The Hamburg-based sponsor has appointed Lazard to advise on the process for Westbridge, which specialises in sustainability management for the real estate and housing industries, the sources said. A sale process is expected to kick off next year, one source said.
Defective cytoskeletal dynamics underlies the essential role of MRTF-SRF in IL-2 delivery to CD8+ T cells during infectious challenge
Abstract Paracrine IL-2 signalling underpins late primary CD8+ T cell expansion and differentiation that allow protection against viral infections, yet the requirements for effective delivery of IL-2 to recipient cells remain poorly understood. We show that the SRF transcription factor, a master regulator of cytoskeletal dynamics, is essential for the response to L. monocytogenes infection.
ACPS Automotive owners Towerbrook, Bridgepoint test waters for exit, Macquarie on sellside – sources - Mergermarket
ACPS Automotive’s backers Towerbrook and Bridgepoint have appointed Macquarie to explore exit scenarios for the German automotive supplier, three sources familiar with the situation told Mergermarket. The vendors are sounding the market and reaching out to potential strategic buyers to assess interest in the towbar and hitch specialist, one of the sources said, adding that a formal sale process could kick off later this year.
TD wants review of Chinese-owned CCTV in Leinster House
A Green Party TD has written to the Ceann Comhairle of the Dáil asking him to review the use of Chinese-owned security cameras in Leinster House.
German health minister’s ‘locust’ sponsor comments spook live healthcare deals -...
New investors scared by minister’s remarks on limiting outpatient profit Rush to consolidate and buy ‘plan hospitals’ before any new laws Small clinics with succession problems hurry to exit Sponsors are rethinking new platform deals in German healthcare following stark remarks by Health Minister Karl Lauterbach that push to curtail private investment in the outpatient sector, market sources watching the situation told Mergermarket.
Datamars owner explores strategic options ahead of potential EUR 1bn-plus sale -...
Canada’s Caisse de dépôt et placement du Québec (CDPQ) is exploring strategic options for its stake in agricultural technology specialist Datamars, according to two sources familiar with the matter. The institutional investor has asked Goldman Sachs to survey options including a sale of the Switzerland-headquartered firm, whose livestock management and reunification technologies are used by veterinarians and farmers worldwide, the sources said.
Metropolis: Berlin's startup scene dominates German tech M&A
Once best known to investors as a hub of unemployment and industrial dereliction, Berlin has emerged over the past decade to became Germany’s leading startup metropolis. In 2021, 273 Berlin-based startups and tech companies raked in a record EUR 14.3bn in buyout, growth and early-stage funding, accounting for 26.6% of the deal volume in Germany (EUR 53.7bn) last year, according to Unquote data.
SEC Seeks to Enhance Disclosures and Provide Additional Investor Protections Related to SPACs
Citing the “unprecedented surge” in the number of initial public offerings by special purpose acquisition companies (SPACs) over the past two years, the SEC has proposed new rules that would require enhanced disclosures and provide additional investor protections in initial public offerings by SPACs and in “de-SPAC” transactions. To date, the SEC has relied on the comment process and staff guidance to shape SPAC-related disclosures in registration statements and proxy statements.
Keeping up with heightened consumer expectations in financial services
ByPatrick Costello, Senior Product Strategy Director, Optimizely The shift from physical banking in branches to online banking services is by no means a new trend. But the gradual move from traditional banking towards new technologies such as online and mobile banking has dramatically accelerated over the last two years as a result of the pandemic, where consumers had no choice but to turn to their laptops or smartphones to manage their finances and make payments.
Three ways to reduce uncertainty in financial services marketing
Rodolphe Harand, Managing Director at YesWeHack Financial services have been one of the most heavily targeted industries by cybercriminals for several years. One alarming stat from the Boston Consulting Group found these firms to be 300x as likely as other companies to be targeted by cyberattacks. Furthermore, the pandemic has led to a significant increase in the number of cyberattacks targeting financial institutions (FIs), with around 74% experiencing a spike in threats linked to COVID-19.
Revising America’s Defense Strategy to Address China’s Rising Aggression
America’s intensifying competition with China is one of the defining features of geopolitics in the 21st century. Please join the American Security Project for an on-the-record discussion on Thursday, November 4 with Elbridge Colby, former Deputy Assistant Secretary of Defense for Strategy and Force Development and author of the newly released book The Strategy of Denial: American Defense in an Age of Great Power Competition.
Road Trip Review: The 2021 Ford Mustang Mach-E from California to Colorado
The Car 2021 Mustang Mach-E 4x First Edition in Grabber Blue Metallic. This specific one has AWD, an 88-kWh battery, 346 hp and 428 lb-ft of torque, and 270 miles of range. The total MSRP is $50,800. The Trip Venice, CA to Denver, CO. 800 miles on the highway, then another 500 miles on back roads (paved and unpaved) through Aspen (fancy!), over Independence Pass (best road in the USA) into Twin Lakes, then onto Colorado Springs to climb Pikes Peak, before relinquishing the car in Denver.
Read, Share and Shape the News
Poll: Do you plan on doing Christmas shopping earlier this year? INDUSTRY GROUP RETAIL Excellence has urged people to consider doing their Christmas shopping earlier than usual this year. In an article in today’s Irish Times, the group’s chief executive said this is to spread out the shopping period to encourage social distancing among shoppers. Duncan Graham also said that supply chain issues as a result of Covid-19 could lead to some shortages, but will you be taking up the advice?
Poll: Do you plan on doing Christmas shopping earlier this year?
Embed this post To embed this post, copy the code below on your site 600px wide 400px wide 300px wide
Opinion: Foster care is in trouble in Ireland and its privatisation is not the answer
AS THIS GOVERNMENT’S term began a broad alliance of civil society groups came together to campaign to save the Department of Children and Youth Affairs. The campaign worked, the department kept its seat at the Cabinet table, a positive first step by the new government given the challenges the department faces. The new program for government states that this administration will “support the ongoing development of fostering services across the country”.
Chronic mast cell leukaemia with exon 9 KIT mutation A502_Y503dup: a rare imatinib responsive variant
Chronic mast cell leukaemia with exon 9 KIT mutation A502_Y503dup: a rare imatinib responsive variant Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways. Copyright information: © BMJ Publishing Group Limited 2020. No commercial re-use.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Patrick
Contact Patrick, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack