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Articles by Patrick J Metz
FERC Prepares to Launch Long-Awaited MBR Relational Database | JD Supra
Significant changes to the market-based rate (MBR) program administered by the Federal Energy Regulatory Commission (FERC) will begin rolling out in the next couple of weeks. In Order No. 860 (FERC Docket No. RM16-17), FERC established a new requirement for MBR sellers to submit a variety of information into a new “relational database.” While the roll-out of this new MBR database was delayed by six months due to COVID, the database is now set to launch on 1 April 2021.
Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling
Highlights • A limited set of mRNA transcripts requires spliceosome methylation for processing • PRMT5 has a conserved role in the induction of antiviral interferon responses • PRMT5 controls IFNB1 and IFNL1 transcription via activation of ATF2, c-Jun, and TBK1 • Altered ATF2 splicing is insufficient on its own to repress interferon signaling Summary Alternative splicing is well understood to enhance proteome diversity as cells respond to stimuli.
ITC Decision Could Cloud Outlook for Solar Project Developers
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Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool
Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool Jane E. Klann, Kelly A. Remedios, Stephanie H. Kim, Patrick J. Metz, Justine Lopez, Lauren A. Mack, Ye Zheng, Mark H. Ginsberg, Brian G. Petrich, John T. Chang The Journal of Immunology June 15, 2017, 198 (12) 4639-4651; DOI: 10.4049/jimmunol.1601165
Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool
Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool Jane E. Klann, Kelly A. Remedios, Stephanie H. Kim, Patrick J. Metz, Justine Lopez, Lauren A. Mack, Ye Zheng, Mark H. Ginsberg, Brian G. Petrich, John T. Chang The Journal of Immunology May 17, 2017, 1601165; DOI: 10.4049/jimmunol.1601165
D.C. Circuit Tells FERC to Try Again on Utility Rates of Return
The Decision: The D.C. Circuit vacated a landmark FERC order, requiring the Commission to provide a rational explanation of its policy for setting the rate of return on equity for electric utilities. The Impact: In the short term, the decision will cause uncertainty regarding the rates of return electric utilities are allowed to earn through FERC-approved rates.
Integrin activation controls regulatory T cell identity and stability
Maintenance of the regulatory T (T ) cell pool is essential for peripheral tolerance and prevention of autoimmunity. Integrins, heterodimeric transmembrane proteins consisting of α and β subunits that mediate cell-cell and cell-extracellular matrix interactions, have been shown to play an important role in facilitating cell contact-mediated suppression by T cells.
Proteasome degradative activity regulates CD8+ T lymphocyte metabolism and fate specification
During an immune response to microbial infection, CD8+ T lymphocytes can undergo asymmetric division, giving rise to daughter cells that exhibit distinct tendencies to adopt the terminal effector and memory fates. Here we show that ‘pre-effector’ and ‘pre-memory’ cells arising from the first CD8+ T cell division in vivo exhibit low and high rates of proteasome degradative activity, respectively.
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