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Articles by Patrick LaChance
Distinct cortical spatial representations learned along disparate visual pathways
Abstract INTRODUCTION METHODS RESULTS DISCUSSION Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Recent experimental studies have found diverse spatial properties, such as head direction tuning and egocentric tuning, of neurons in the postrhinal cortex (POR) and revealed how the POR spatial representations are distinct from the retrosplenial cortex (RSC).
Diversity and sensorimotor specialization of head direction cells in the mouse thalamus
Surgical procedures In vivo extracellular recordings in head-fixed mice Surgical procedures were performed as previously described.65,66 Briefly, mice were induced with 4% isoflurane (IsoFlo, Zoetis Inc.) in carboxygen (flow rate 2L/min) and maintained with 1-2% isoflurane following a subcutaneous injection of buprenorphine (at 0.1 mg/kg, Vetergesic). The scalp was clipped, sterilized, and injected with bupivacaine (Marcain).
Internal and external codes for location - Nature Neuroscience
When navigating through the world, we can predict our next location on the basis of an internal sense of our location and velocity, but we can also orient to external visual sensory cues to update and stabilize this sense of location and velocity. A new experiment that mismatches the speed of visual cues and physical movement in rats shows that hippocampal network dynamics rapidly alternate between these functions within cycles of the 8-Hz theta oscillation.
Translational differentiation of vertically displaced surfaces by grid cells
Keywords entorhinal cortex grid cells navigation spatial orientation 3D space path integration active vs. passive movement Get full text access Log in, subscribe or purchase for full access. References 1. O'Keefe, J. ∙ Nadel, L. The Hippocampus as a Cognitive Map 2. Fyhn, M. ∙ Molden, S. ∙ Witter, M.P. ... Spatial representation in the entorhinal cortex Science. 2004; 305:1258-1264 3. Hafting, T. ∙ Fyhn, M. ∙ Molden, S. ... Microstructure of a spatial map in the entorhinal cortex Nature. 2005; 436:801-806 4.
How do egocentric boundary cells depend upon the coordinate system of environmental features?
Abstract Neurons in the retrosplenial (RSC) (Alexander et al., 2020a; LaChance and Hasselmo, 2024) and postrhinal cortex (POR) respond to environmental boundaries and configurations in egocentric coordinates relative to an animals current position. Neurons in these structures and adjacent structures also respond to spatial dimensions of self-motion such as running velocity (Carstensen et al., 2021; Robinson et al., 2024).
Distinct cortical spatial representations learned along disparate visual pathways
Abstract Recent experimental studies have discovered diverse spatial properties, such as head direction tuning and egocentric tuning, of neurons in the postrhinal cortex (POR) and revealed how the POR spatial representation is distinct from the retrosplenial cortex (RSC). However, how these spatial properties of POR neurons emerge is unknown, and the cause of distinct cortical spatial representations is also unclear.
Distinct codes for environment structure and symmetry in postrhinal and retrosplenial cortices - Nature Communications
Abstract Complex sensory information arrives in the brain from an animal’s first-person (‘egocentric’) perspective. However, animals can efficiently navigate as if referencing map-like (‘allocentric’) representations. The postrhinal (POR) and retrosplenial (RSC) cortices are thought to mediate between sensory input and internal maps, combining egocentric representations of physical cues with allocentric head direction (HD) information.
The Anterior Thalamus Preferentially Drives Allocentric But Not Egocentric Orientation Tuning in Postrhinal Cortex
The Anterior Thalamus Preferentially Drives Allocentric But Not Egocentric Orientation Tuning in Postrhinal Cortex Patrick A. LaChance, Jeffrey S. Taube Journal of Neuroscience 6 March 2024, 44 (10) e0861232024; DOI: 10.1523/JNEUROSCI.0861-23.2024
The anterior thalamus preferentially drives allocentric but not egocentric orientation tuning in postrhinal cortex
Abstract Navigating a complex world requires integration of multiple spatial reference frames, including information about one's orientation in both allocentric and egocentric coordinates. Combining these two information sources can provide additional information about one's spatial location.
Comparison of head direction cell firing characteristics across thalamo‐parahippocampal circuitry
REFERENCES , , , & (2023). Population dynamics of head-direction neurons during drift and reorientation. Nature, 615, 892–899. , , , , , & (2020). Egocentric boundary vector tuning of the retrosplenial cortex. Science Advances, 6, eaaz2322. , , , , , & (2013). Optic flow stimuli update anterodorsal thalamus head direction neuronal activity in rats. Journal of Neuroscience, 33(42), 16790–16795. https://doi.org/10.1523/JNEUROSCI.2698-13.2013 , & (2001).
Geometric determinants of the postrhinal egocentric spatial map
A purely geometric module in the rat’s spatial representation. Cognition. 1986; 23: 149-178https://doi.org/10.1016/0010-0277(86)90041-7 The Organization of Learning. Bradford Books/MIT Press, 1990 Reflections on geometry and navigation. Conn. Sci. 2005; 17: 5-21https://doi.org/10.1080/09540090500138077 Is there a geometric module for spatial orientation? Squaring theory and evidence. Psychon. Bull. Rev. 2005; 12: 1-23 Cheng K. Huttenlocher J.
North American diadromous fishes: Drivers of decline and potential for recovery in the Anthropocene
John R. Waldman https://orcid.org/0000-0001-6989-0142 and Thomas P.
Landmark-modulated directional coding in postrhinal cortex
Patrick A. LaChance https://orcid.org/0000-0003-1477-064X, Jalina Graham https://orcid.org/0000-0003-2189-4157, Benjamin L. Shapiro https://orcid.org/0000-0002-9300-7695, Ashlyn J. Morris, and Jeffrey S. Taube https://orcid.org/0000-0001-6487-0791 Abstract INTRODUCTION RESULTS DISCUSSION METHODS Acknowledgments Supplementary Materials REFERENCES AND NOTES Abstract Visual landmarks can anchor an animal’s internal sense of orientation to the external world.
Electronic skin as wireless human-machine interfaces for robotic VR
Yiming Liu https://orcid.org/0000-0003-0134-1934, Chunki Yiu https://orcid.org/0000-0003-3841-5327, Zhen Song https://orcid.org/0000-0002-0726-2455, Ya Huang https://orcid.org/0000-0002-0965-8226, Kuanming Yao https://orcid.org/0000-0001-8744-8892, Tszhung Wong https://orcid.org/0000-0001-5890-2523, Jingkun Zhou https://orcid.org/0000-0001-5394-4388, … Show All … , Ling Zhao, Xingcan Huang https://orcid.org/0000-0003-4210-2470, Sina Khazaee Nejad https://orcid.org/0000-0001-7111-3051, Mengge...
Geographically targeted COVID-19 vaccination is more equitable and averts more deaths than age-based thresholds alone
Elizabeth Wrigley-Field https://orcid.org/0000-0003-3489-4279 [email protected], Mathew V. Kiang https://orcid.org/0000-0001-9198-150X, Alicia R. Riley https://orcid.org/0000-0002-3341-6892, Magali Barbieri https://orcid.org/0000-0003-3501-4034, Yea-Hung Chen https://orcid.org/0000-0002-7949-0692, Kate A. Duchowny, Ellicott C.
Commutative Properties of Head Direction Cells during Locomotion in 3D: Are All Routes Equal?
Research Articles, Systems/Circuits Patrick A. LaChance, Julie R. Dumont, Pelin Ozel, Jennifer L. Marcroft and Jeffrey S. Taube Journal of Neuroscience 8 April 2020, 40 (15) 3035-3051; DOI: https://doi.org/10.1523/JNEUROSCI.2789-19.2020 Abstract Navigation often requires movement in three-dimensional (3D) space. Recent studies have postulated two different models for how head direction (HD) cells encode 3D space: the rotational plane hypothesis and the dual-axis model.
Commutative Properties of Head Direction Cells During Locomotion in 3D: Are All Routes Equal?
Research Articles, Systems/Circuits Patrick A. LaChance, Julie R. Dumont, Pelin Ozel, Jennifer L. Marcroft and Jeffrey S. Taube Journal of Neuroscience 3 March 2020, 2789-19; DOI: https://doi.org/10.1523/JNEUROSCI.2789-19.2020 Abstract Navigation often requires movement in three-dimensional (3D) space. Recent studies have postulated two different models for how head direction (HD) cells encode 3D space — the rotational-plane hypothesis and the dual-axis model.
A sense of space in postrhinal cortex
From local space to higher-order maps Successful movement depends on an accurate sense of one's location within a particular environment. Neuroscientists distinguish self-centered and world-centered navigation and have been searching for a brain region where all ingredients of navigation come together. As rats foraged in an open field, LaChance et al. recorded activity from single neurons in an area called the postrhinal cortex.
Early Life Stress Drives Sex-Selective Impairment in Reversal Learning by Affecting Parvalbumin Interneurons in Orbitofrontal Cortex of Mice
Highlights • Early life stress leads to select deficits in reversal learning in female mice • Impaired rule-reversal learning is associated with decreased PV and GAD67 in OFC • Optogenetic silencing of OFC PV+ cells recapitulates ELS effects on reversal learning • Optogenetic silencing of mPFC PV+ cells impairs rule shifting, but not reversal learning Summary Poverty, displacement, and parental stress represent potent sources of early life stress (ELS).
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