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Articles by Patrick Lévy
New friends, old enemies and a vanishing retirement fund: Welcome to the Golden Age
To the editor: The United States was only able to send three people over to Myanmar to help with the 7.7 magnitude earthquake. Boy, is that sad. Making America great again? Does that include the $5 trillion out of people’s retirement accounts that vaporized last week or the $5.7 trillion that the U.S. Senate and House will be adding to the deficit in the next couple of weeks with Trump’s new tax cut bill for billionaires?
Sleep apnoea and the heart
SDB and heart failure: cause or effect? Heart failure represents a clinical phenotype resulting from acute or chronic development of cardiac and extra-cardiac diseases. Hypertension, cardiomyopathies, including CAD, and valvulopathies are common cardiac causes of heart failure, while clinical conditions such as kidney dysfunction, widespread atherosclerosis, diabetes mellitus, and lung and thyroid gland diseases could also favour the development of cardiac dysfunction.
"L’accompagnement humain est la clé de l’efficacité des partenariats territoriaux"
Par leur action quotidienne dans les territoires, nos entreprises de travail temporaire sont fortement contributrices à l’objectif de plein emploi, l’une des priorités du quinquennat. L’engagement de notre secteur se traduit par de nombreuses initiatives de Prism’emploi, lancées à l’échelle nationale puis déclinées en région, qui visent à favoriser le retour à l’emploi des personnes qui en sont éloignées.
Reply to: Muscle sympathetic nerve activity and adaptive servo-ventilation: questions remain
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Reply to: Central apnoeas, sympathetic activation and mortality in heart failure: look before you leap
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Effect of adaptive servo-ventilation for central sleep apnoea in systolic heart failure on muscle sympathetic nerve activity: a SERVE-HF randomised ancillary study
Abstract Background Adaptive servo-ventilation (ASV) effectively suppresses central sleep apnoea (CSA) but has been associated with increased all-cause and cardiovascular mortality in chronic heart failure patients with reduced ventricular ejection fraction (HFrEF). All-cause and, especially, cardiovascular mortality in chronic heart failure is highly correlated with sympathetic tone. This analysis of SERVE-HF data investigated the effect of ASV on sympathetic tone in patients with HFrEF and CSA.
Are type III devices the future of sleep disordered breathing management?
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Elections matter
To the editor: Hopefully we will see more than 17% of Alaskans turning out to vote, as that was the turnout from our last municipal election. Outside money is flooding in to support our Arizona candidate for U.S. Congress, Sarah Palin … wait, did she move back to Alaska to run? One of our other U.S. congressional candidates, Nick Begich, loaned his campaign a whopping $650,000 of his own money. I guess we should all be wondering how he plans on repaying that “loan”?
Effect of adaptive servo-ventilation for central sleep apnoea in systolic heart failure on muscle sympathetic nerve activity: a SERVE-HF randomised ancillary study
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Sleep apnoea and heart failure
European Respiratory Journal 59: 2101640; DOI: 10.1183/13993003.01640-2021 Abstract Heart failure and sleep disordered breathing (SDB) are two common conditions that frequently overlap and have been studied extensively in the past three decades. Obstructive sleep apnoea (OSA) may result in myocardial damage due to intermittent hypoxia that leads to increased sympathetic activity and transmural pressures, low-grade vascular inflammation, and oxidative stress.
Some forgotten issues in sleep apnoea
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Overcoming travel adversities Original
To the editor: We all know that we are living in difficult pandemic times. Up here in Fairbanks during the winter we all rely on air travel to connect us with our families and loved ones in faraway lands.
Sleep Apnoea and Heart Failure
Patrick Lévy, Matt T Naughton, Renaud Tamisier, Martin R Cowie, T. Douglas Bradley European Respiratory Journal 2021; DOI: 10.1183/13993003.01640-2021 Abstract Heart Failure (HF) and Sleep-Disordered-Breathing (SDB) are two common conditions that frequently overlap and have been studied extensively in the past three decades.
The search for realistic evidence on the outcomes of obstructive sleep apnoea
Sophia Schiza, Patrick Lévy, Miguel Angel Martinez-Garcia, Jean-Louis Pepin, Anita Simonds, Winfried Randerath European Respiratory Journal 2021 58: 2101963; DOI: 10.1183/13993003.01963-2021 Abstract The reported effect of CPAP on cardiovascular outcomes in sleep apnoea should be interpreted with caution and several factors must be considered before definite conclusions can be drawn https://bit.ly/3lLQG4d Footnotes Conflict of Interest: S. Schiza has nothing to disclose. Conflict of interest: P.
Enough With Bill O'Reilly
To the editor: I read the opinion piece by serial sexual harasser, Bill O’Reilly, in the March 26 FDNM. It reminded me of the Letter to the Editor placed with the FDNM on Jan. 17 titled “A Full & Complete Explanation On Kevin Clarkson.” That letter was requesting that Gov. Dunleavy explain why he and his chief of staff broke the law by allowing our ex-state AG, a sexual harasser, remain in his position for so long.
In support of NPR
To the editor: I read Paul Barrett’s Letter to the Editor with interest, as it appears that I just missed him in Valdez. I moved there in 1979 and lived there for seven years. A big thing that initially impacted me was the lack of local radio and only a low power repeater that was rebroadcasting an Anchorage commercial radio station, as Mr. Barrett mentioned.
Bill O'Reilly, sexual harasser
To the editor: We live in truly strange times. A virus ravages our country, and when I write this, I note we have unnecessarily lost over 195,000 Americans to this pandemic. Our president, the leader of the GOP, demands loyalty from all members. Even during this pandemic, our governor and U.S. Sen.
Assessment of sleep‐disordered‐breathing: Quest for a metric or search for meaning?
When Christian Guilleminault described, with Bill Dement, the concept of sleep apnea syndromes (Guilleminault, Eldridge, & Dement, 1973), it actually referred to previous observations of various forms of manifestation of cessation of breathing during sleep that had been reported since the 19th century (Lavie, 2008).
An insomnia expert answers a huge question about social isolation
As a philosopher who researches insomnia, I’m struck by how similar the lockdown experience is with lying awake through the night, waiting for either sleep to come or the new day to dawn. In particular, it is this warped relationship with time and the type of discomfort involved that makes the two experiences similar. I’ve found this analogy of likening lockdown to insomnia helpful for understanding the current situation and for evaluating how we respond to it.
Easier access to mechanical ventilation worldwide: an urgent need for low income countries, especially in face of the growing COVID-19 crisis
Claude Guérin, Patrick Lévy European Respiratory Journal 2020 55: 2001271; DOI: 10.1183/13993003.01271-2020 Abstract Combining easy-to-build noninvasive ventilator and open-source hardware description, may allow for adequate availability of ventilators to patients in low- and middle-income countries. This is urgently needed in the growing COVID-19 epidemic.
Why lockdown life is a lot like insomnia - a philosopher of sleep explains
As a philosopher who researches insomnia, I’m struck by how similar the lockdown experience is with lying awake through the night, waiting for either sleep to come or the new day to dawn. In particular, it is this warped relationship with time and the type of discomfort involved that makes the two experiences similar. I’ve found this analogy of likening lockdown to insomnia helpful for understanding the current situation and for evaluating how we respond to it.
Why Lockdown Life Is A Lot Like Insomnia
Shutterstock As a philosopher who researches insomnia, I’m struck by how similar the lockdown experience is with lying awake through the night, waiting for either sleep to come or the new day to dawn. In particular, it is this warped relationship with time and the type of discomfort involved that makes the two experiences similar. I’ve found this analogy of likening lockdown to insomnia helpful for understanding the current situation and for evaluating how we respond to it.
Easier access to mechanical ventilation worldwide: an urgent need for low income countries, especially in face of the growing COVID-19 crisis
Claude Guérin, Patrick Lévy European Respiratory Journal 2020; DOI: 10.1183/13993003.01271-2020 Abstract Combining easy-to-build non-invasive ventilator and open-source hardware description, may allow for adequate availability of ventilators to patients in low-to-middle-income countries. This is urgently needed in the growing COVID-19 epidemic. Positive-pressure mechanical ventilation saving lives was proved during the poliomyelitis epidemics of the 1950s.
Suboptimal CPAP adherence: half a loaf is better than no bread at all
Martha E. Billings, Patrick Lévy, Najib Ayas European Respiratory Journal 2020 55: 2000144; DOI: 10.1183/13993003.00144-2020 Abstract Suboptimal CPAP use, less than 4 h per night, may still have beneficial effects on daytime sleepiness. Removing CPAP in those who routinely use it for 2–3 h a night worsened their daytime sleepiness.
No Alaska ‘bar wars’ over proposed regulation
I am heartened to see an overwhelming and united response in opposition to the latest attempt from the state Alcohol and Marijuana Control Office to further restrict the new alcohol licenses for breweries, distilleries, and wineries. It is my understanding that even the AMCO board does not support the new proposed language that the director and staff have presented to them and the public as a new section of the Alaska Administrative Code (3 AAC 304.390 Definitions).
Management of hypertension in obstructive sleep apnoea: predicting blood pressure reduction under continuous positive airway pressure
Hypertension affects a quarter of the adult population and remains a leading cause of cardiovascular mortality, accounting for 13.5% of all deaths. Half of all strokes and ischaemic heart disease events are attributable to high blood pressure (BP) [1, 2]. Most patients exhibit Grade-I hypertension (systolic BP of 140 to 159?mmHg and/or diastolic BP of 90 to 99?mmHg) without co-existing cardiovascular disease.
Do patients with obstructive sleep apnoea deserve new dedicated antihypertensive strategies?
Hypertension affects 25% of the adult population and remains a leading cause of cardiovascular mortality, accounting for 13.5% of all deaths. Half of all strokes and ischaemic heart disease events are attributed to hypertension.1 ,2 Most patients exhibit grade I hypertension (systolic blood pressure of 140–159?mm?Hg and/or diastolic blood pressure of 90–99?mm?Hg) without coexisting cardiovascular disease.
Do patients with obstructive sleep apnoea deserve new dedicated antihypertensive strategies?
Hypertension affects 25% of the adult population and remains a leading cause of cardiovascular mortality, accounting for 13.5% of all deaths. Half of all strokes and ischaemic heart disease events are attributed to hypertension.1 ,2 Most patients exhibit grade I hypertension (systolic blood pressure of 140–159?mm?Hg and/or diastolic blood pressure of 90–99?mm?Hg) without coexisting cardiovascular disease.
Obstructive sleep apnoea in acute coronary syndrome: the invisible threat?
Worldwide, coronary artery disease (CAD) is the single most common cause of death [1]. Over seven million people every year die from CAD, accounting for 13.2% of all deaths [1, 2]. The presentation of acute coronary syndrome (ACS) can be unstable angina, non-ST elevation myocardial infarction (NSTEMI) or ST elevation myocardial infarction (STEMI) [1, 3].Obstructive sleep apnoea (OSA) is a common comorbidity in patients with ACS.
Normoxic Recovery Reverses Intermittent Hypoxia-Induced Systemic and Vascular Inflammation
Second, the authors mentioned that aortic wall remodeling is “the result of multiple interactions between intermediary mechanisms, including oxidative stress, systemic and tissue inflammation,” but they do not investigate the impact of IH removal on these parameters.
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