Patrick Macdonald
As seen in:
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Science Magazine,
Cell Metabolism,
ADVFN,
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Kelowna Daily Courier,
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Articles by Patrick Macdonald
Multiplexed deep visual proteomics resolves spatial heterogeneity and rare endocrine states in human pancreatic islets
Abstract Understanding tissue function requires connecting spatial cellular context with molecular depth, yet such integration remains challenging in complex organs like the pancreas. We develop multiplexed Deep Visual Proteomics (mxDVP), an end-to-end workflow combining high-plex imaging, automated computational analysis, and spatially guided ultra-sensitive mass spectrometry.
The comparative cell physiology of stem cell-derived and primary human β cells
Abstract The ability to generate stem cell-derived pancreatic β (SCβ) cells and stem cell-derived islets has opened new opportunities for type 1 diabetes mellitus therapies and disease modelling. Carefully assessing how closely SCβ cells resemble their primary counterparts is crucial to the support of ongoing clinical trials and human-centric studies on diabetes pathophysiology.
Supervised machine learning identifies impaired mitochondrial quality control in β-cells with development of type 2 diabetes
Abstract Defining molecular pathways driving β-cell failure in type 2 diabetes (T2D) is challenging given donor heterogeneity. We developed an interpretable machine learning framework coupling sparse rule-based classification, pathway constrained modeling, and mitochondrial fitness stratification, applied to single-cell RNAseq from 52 human islet donors. A 50-gene classifier predicted T2D at single-cell resolution, outperforming ensemble models, with donor-level scores correlating with HbA1c.
TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network
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Abstract A main mechanism of β-cell dysfunction in diabetes is loss of identity, controlled by transcription factors that induce identity gene expression and disallowed gene repression. How transcription factors facilitate simultaneous expression and repression is not fully understood, representing a knowledge gap in diabetes research.
By Alina Walth-Hummel, Celine Jouffe, Peter Weber, Karsten Motzler, Julia Geppert, Michael Sterr, Wei Gan, Iwona Szczerbinska, Ann-Christine König, Stefanie Hauck, Daniela Hass, Congcong Wang, Kenneth A. Dyar, James Lyon, Heiko Lickert, Carina Ämmälä, Stephan Herzig, Frances M. Ashcroft, Mostafa Bakhti, Patrick Macdonald, Maria Rohm, Raul Terron-Exposito
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Nature
Verified
Persistent organic pollutant concentrations in human pancreas correlate with markers of beta cell dysfunction
Abstract Epidemiological studies consistently report associations between circulating concentrations of persistent organic pollutants and increased type 2 diabetes risk. Measures of pollutant concentrations in pancreas are limited; given the role of the endocrine pancreas in diabetes pathogenesis, this is an important gap in the literature. Additionally, no studies have correlated pollutant concentrations with direct measures of human beta cell function.
Spatially bound functional heterogeneity drives modular organization in β-cell networks
Significance Understanding how β-cells coordinate their responses to fluctuating nutrient levels is vital for unraveling the mechanisms of insulin secretion. Our findings reveal that β-cells with similar Ca2+ signaling characteristics cluster together, forming highly modular networks that include specialized subpopulations such as hub, wave initiator, and first responder cells.
Report of foreign issuer [Rules 13a-16 and 15d-16]
UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 under the Securities Exchange Act of 1934 For the month of April 2025 Commission File Number 001-15144 TELUS CORPORATION (Translation of registrant's name into English) 23rd Floor, 510 West Georgia Street Vancouver, British Columbia V6B 0M3 Canada (Address of principal executive office) Indicate by check mark whether the registrant files or will...
HumanIslets.com: Improving accessibility, integration, and usability of human research islet data
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ForumVolume 37, Issue 1p7-11 1Institute of Parasitology, McGill University, Montreal, QC, Canada 2Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA 3Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada 4Department of Pharmacology, University of Alberta, Edmonton, AB, Canada 5Department of Surgery, University of Alberta, Edmonton, AB, Canada 6Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia,...
By Jessica D. Ewald, Yao Lu, Cara E. Ellis, Jessica Worton, Jelena Kolic, Shugo Sasaki, Dahai Zhang, Theodore dos Santos, Aliya F. Spigelman, Austin Bautista, Xiao-Qing Dai, James Lyon, Nancy Smith, Jordan Wong, Varsha Rajesh, Han Sun, Seth Sharp, Jason C. Rogalski, Renata Moravcová, Haoning Cen, Ella Atlas, Jennifer E. Bruin, Erin E. Mulvihill, C. Bruce Verchere, Leonard Foster, Anna L Gloyn, James Johnson Verified, Andrew R. Pepper, Francis C. Lynn, Jianguo Xia, Patrick Macdonald
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Cell Metabolism
Verified
Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease
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Keywords human islets type 2 diabetes stem cell-derived islets insulin secretion proteomics macronutrients RNA-seq Introduction Insulin is released by pancreatic islet beta cells in response to nutrient stimuli to maintain energy homeostasis. The major driver of insulin secretion is glucose. However, proteins and fats may also modulate insulin release, and the effects of non-carbohydrate nutrients on insulin secretion remain underexplored.
By Jelena Kolic, Wenqing Sun, Haoning Cen, Jessica D. Ewald, Jason C. Rogalski, Shugo Sasaki, Han Sun, Varsha Rajesh, Yi Xia, Renata Moravcová, Søs Skovsø, Aliya F. Spigelman, James Lyon, Leanne Beet, Jianguo Xia, Francis C. Lynn, Anna L Gloyn, Leonard Foster, Patrick Macdonald, James Johnson Verified
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Cell Metabolism
Verified
Junior Season Highlights - 7 games
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MLS is What it Is, Jurgen, Deal With It
By Patrick MacDonald The World Cup Qualifying campaign for Russia 2018 starts in 8 days. Can you believe it? Probably not because if you look at the blogs, websites, and other media that normally cover the Men's National Team, there's nary a whisper. They're either consumed with covering the MLS playoffs or the upper echelons of European action.
Gulati Needs to Boot Klinsmann if He Can't Beat Mexico
By Patrick MacDonald Did you see it? As Jermaine Jones left the field in the 72nd minute last night during what was then a 4-0 demolition at the hands of Brazil, Jones refused to shake Jurgen Klinsmann's hand. The man who took years to finally win over U.S. fans, refused to grant the man who's steadfastly been in his corner in the most trying times of his national team career, a basic courtesy. That's telling. Isn't it?
Poilievre is terrifying
Dear Editor: I have heard/read recent comments that Pierre Poilievre is making people “nervous.” What an understatement. Pierre Poilievre is terrifying – and not only because of his introduction to Canada the Republican U.S. style of politics. No, it goes much further than that.
Federal Reserve Releases Additional Terms And Conditions And FAQs On The Term Asset-Backed Securities Loan Facility (TALF)
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I'm gay. I work in marketing. I'll still be drinking Coopers - Mumbrella
The 'Keeping it Light' video was an abomination of biblical proportions, says Ballistics Marketing & Communications' MD Patrick MacDonald, but here, he argues the brand's badly executed good intentions don't need to be crucified any further. Let’s get one thing straight. The “Keeping it Light” video was terrible. For one thing, had the producers learned nothing from Amber Sherlock? What were they thinking putting three men in the exact same colour jacket on screen?
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