Paul J Tyler on Muck Rack

Paul J Tyler

Australia
As seen in: Science Magazine, 101FM Logan City
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Articles

Loss of the autoimmune risk gene TREX1 reveals a convergence of mechanisms promoting immune tolerance loss and antitumor immunity

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By Valdemar Priebe, Peter Sheridan Dodds, Mohammad A Saad, Junghyun Lim, Katherine Williams, Stephanie Mittman, Patricia Sanchez, Patricia Sánchez Verified, Ryan Rodriguez, Annie Ogasawara, Grace Barnett, Mayra Cruz Tleugabulova, Barzin Y. Nabet, Jeffrey Hung, Kevin Marroquín, Shari Lau, Serena Lee, Paul J Tyler, Elizabeth Carbone, Herman Gill, Bridget Hough, Janice Corpuz, Haruka Murota, Edward Dere, Smadar Shiffman, Leah K. Schutt
| Science Magazine Verified
Abstract Checkpoint inhibitors targeting PD-1 and CTLA-4 have transformed cancer therapy. Both are genetically associated with autoimmune disorders. Moreover, certain immune-related adverse events and autoimmune risk variants are linked to the clinical efficacy of checkpoint inhibition. These associations suggest common principles governing successful cancer immunotherapy and autoimmune susceptibility.
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