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Junghyun Lim

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Articles

Trans-ancestry genome-wide association meta-analysis of gallstone disease

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By Junghyun Lim, Marijana Vujkovic, Michael Levin, Kim Lorenz, Benjamin F Voight, David Zhang, Matthew C. Pahl, James Pippin, Chun Su, Elisabetta Manduchi, Andrew Wells, Struan F. A. Grant, Sarah A Abramowitz, Scott M. Damrauer, Samiran Mukherjee, Guoyi Yang, Lindsay A. Guare, Shefali Setia-Verma, DAVID KAPLAN, Daniel Rader, Max. F. Dudek
| Nature Verified
Abstract Gallstone disease is a highly prevalent and costly gastrointestinal disease. Yet, genetic variation in gallstone susceptibility and its implication in metabolic pathways remain to be explored. We report a trans-ancestry genome-wide association meta-analysis of gallstone disease including 100,856 cases and 1,596,602 controls in the UK Biobank, FinnGen, Biobank Japan, and Million Veteran Program.
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Loss of the autoimmune risk gene TREX1 reveals a convergence of mechanisms promoting immune tolerance loss and antitumor immunity

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By Valdemar Priebe, Peter Sheridan Dodds, Mohammad A Saad, Junghyun Lim, Katherine Williams, Stephanie Mittman, Patricia Sanchez, Patricia Sánchez Verified, Ryan Rodriguez, Annie Ogasawara, Grace Barnett, Mayra Cruz Tleugabulova, Barzin Y. Nabet, Jeffrey Hung, Kevin Marroquín, Shari Lau, Serena Lee, Paul J Tyler, Elizabeth Carbone, Herman Gill, Bridget Hough, Janice Corpuz, Haruka Murota, Edward Dere, Smadar Shiffman, Leah K. Schutt
| Science Magazine Verified
Abstract Checkpoint inhibitors targeting PD-1 and CTLA-4 have transformed cancer therapy. Both are genetically associated with autoimmune disorders. Moreover, certain immune-related adverse events and autoimmune risk variants are linked to the clinical efficacy of checkpoint inhibition. These associations suggest common principles governing successful cancer immunotherapy and autoimmune susceptibility.
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Globalization, internal migration, and public goods provision in emerging economies

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By Benjamin Helms, Junghyun Lim, Kolby Hanson
| Wiley Online Library Verified
Global economic integration—the spread of production across borders—is economically and politically disruptive. Rising import competition creates geographically concentrated economic dislocation that causes a political backlash in advanced economies (Baccini & Weymouth, 2021; Ballard-Rosa, Jensen, & Scheve, 2022; Colantone & Stanig, 2018). Globalization is similarly disruptive for labor markets in emerging economies, though with divergent impacts.
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