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Articles by Pei Lu
Clinical risk factors and machine learning-assisted interpretation of ureteral access sheath insertion failure: a multicenter study and meta-analysis
Abstract Background: In patients undergoing retrograde ureteroscopic lithotripsy, the failure rate of ureteral access sheath insertion is approximately 10%. Temporary double-J stenting with delayed secondary intervention is usually required when insertion fails. However, such cases cannot be reliably identified based on routine preoperative imaging. This study aimed to identify risk factors associated with ureteral access sheath (UAS) insertion failure.
Correction to “Trilocked Photodynamic Senolytic Inducer Potentiating Immunogenic Senescent Cell Removal for Liver Fibrosis Resolution”
We inadvertently missed one methylene group in the β-gal responsive moiety for cAID and cAID-NAc in the schematic illustrations in the published manuscript. The corrected Figure 1a, Figure 2a, Figure 4a and Table of Contents/Abstract graphic are presented below. The Supporting Information has been revised to include the correct drawings and chemical formula for cAID and cAID-NAc. These corrections do not affect the conclusions reported in the published article.
Synergistic Effect of Ribitol and Shikonin Promotes Apoptosis in Breast Cancer Cells
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Efficacy and Safety of Remimazolam in Short Endoscopic Procedures: A Systematic Review and Meta-Analysis
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Antigen specificity shapes antibody functions in tuberculosis.
Abstract Tuberculosis (TB) is the number one infectious disease cause of death worldwide in part due to an incomplete understanding of immunity. Emerging data highlight antibody functions as correlates of protection and disease across human TB. However, little is known about how antibody functions impact Mycobacterium tuberculosis (Mtb), the causative agent. Here, we use antigen specificity to understand how antibodies mediate host-Mtb interactions.
H2O2/Acid Self-Supplying Double-Layer Electrospun Nanofibers based on ZnO2 and Fe3O4 nanoparticles for Efficient Catalytic Therapy of Wound Infection
H2O2/Acid Self-Supplying Double-Layer Electrospun Nanofibers based on ZnO2 and Fe3O4 nanoparticles for Efficient Catalytic Therapy of Wound Infection Catalytic therapy based on nanozymes is a promising method for the treatment of bacterial infections. Nanozymes with peroxidase (POD)-like activity can convert hydrogen peroxide (H2O2) to produce reactive oxygen species (ROS) for killing bacteria, especially those resistant to antibiotics.
Xanthene-Based Near-Infrared Chromophores for High-Contrast Fluorescence and Photoacoustic Imaging of Dipeptidyl Peptidase 4
Xanthene-Based Near-Infrared Chromophores for High-Contrast Fluorescence and Photoacoustic Imaging of Dipeptidyl Peptidase 4 Near-Infrared (NIR) chromophores with analyte tunable emission and absorption properties are highly desirable for developing activatable fluorescence and photoaccoustic (PA) probes for bioimaging and disease diagnosis.
Diverging maternal and cord antibody functions from SARS-CoV-2 infection and vaccination in pregnancy
Maternal immunity impacts the infant but how is unclear. To understand the implications of the immune exposures of vaccination and infection in pregnancy for neonatal immunity, we evaluate antibody functions in paired peripheral maternal and cord blood. We compare those who in pregnancy received mRNA COVID-19 vaccine, were infected by SARS-CoV-2, and the combination.
Metabolic Reprogramming by Ribitol Expands the Therapeutic Window of BETi JQ1 against Breast Cancer
1. Introduction Breast cancer is the most common cancer and one of the leading causes of cancer-related death [1]. The World Health Organization estimates that breast cancer accounted for 12% of all new cancers diagnosed worldwide in 2021 [2]. Several decades of intensive studies have led to impressive progress in early diagnosis and treatment. New drugs targeting many different pathways have been developed and tested in clinical trials.
Diverging maternal and infant cord antibody functions from SARS-CoV-2 infection and vaccination in pregnancy
New Results doi: https://doi.org/10.1101/2023.05.01.538955 Abstract Immunization in pregnancy is a critical tool that can be leveraged to protect the infant with an immature immune system but how vaccine-induced antibodies transfer to the placenta and protect the maternal-fetal dyad remains unclear. Here, we compare matched maternal-infant cord blood from individuals who in pregnancy received mRNA COVID-19 vaccine, were infected by SARS-CoV-2, or had the combination of these two immune exposures.
A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA - Genome Biology
Cell culture and differentiation Two human ESC lines, HUES8 and H9, and one iPSC line PGP1 were used in this study. They were cultured in mTeSR™ medium (STEMCELL Technologies, #05850) on Matrigel-coated plates. Human embryonic kidney 293T (HEK293T) cells were cultured with DMEM medium containing 10% fetal bovine serum (FBS; Gibco, #10270–106) and 1% penicillin–streptomycin (Gibco, #15140163).
Membrane-Tethered Activation Design of Photosensitizer Boosts Systemic Antitumor Immunity via Pyroptosis
Membrane-Tethered Activation Design of Photosensitizer Boosts Systemic Antitumor Immunity via Pyroptosis Pei Lu, Xianjun Liu, Xia Chu, Fenglin Wang and Jian-Hui Jiang Abstract Pyroptotic immunogenic cell death presents an emerging targeting pathway for cancer immunotherapy. We report a novel membrane-tethered activation design of photosensitizer (PS) that boosts systemic anti-tumor immunity to primary and distant tumors via pyroptosis induction.
Design and Optimization of Organic Rankine Cycle Based on Heat Transfer Enhancement and Novel Heat Exchanger: A Review
Abstract : The effective exploitation of renewable energy and the recovery of waste heat are two crucial strategies in achieving carbon neutrality. As an efficient and reliable heat–to–power conversion technology, the organic Rankine cycle (ORC) has been recognized and accepted by academia and industry for use in solar energy, geothermal energy, biomass energy, and waste heat applications.
Ribitol alters multiple metabolic pathways of central carbon metabolism with enhanced glycolysis: A metabolomics and transcriptomics profiling of breast cancer (pdf) | Paperity
PLOS ONE, Dec 2022 This is a preview of a remote PDF: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0278711&type=printable Jason Driver Tucker, Ravi Doddapaneni, Pei Juan Lu, Qi Long Lu. , PLOS ONE, 2022, Volume 17, Issue 12, DOI: 10.1371/journal.pone.0278711
Clustering-Based Segmented Regression for Particulate Matter Sensor Calibration
Open AccessArticle by Sijie Liu 1,2, Xinyu Liu 3 and Pei Lu 1,2,* 1 College of Information Science and Engineering, Guilin University of Technology, Guilin 541004, China 2 Guangxi Key Laboratory of Embedded Technology and Intelligent System, Guilin University of Technology, Guilin 541004, China 3 Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China * Author to whom correspondence should be addressed.
Amylase degradation enhanced NIR photothermal therapy and fluorescence imaging of bacterial biofilm infections
Amylase degradation enhanced NIR photothermal therapy and fluorescence imaging of bacterial biofilm infections† Lihui Yuwen, a Huayu Xiao,a Pei Lu,a Xiaolong Chen,a Jianguang Li,a Weijun Xiu,a Siyu Gan,a Dongliang Yang *b and Lianhui Wang *a Abstract Effective treatment of bacterial biofilm-related infections is a great challenge for the medical community.
Ribitol alters multiple metabolic pathways of central carbon metabolism with enhanced glycolysis: A metabolomics and transcriptomics profiling of breast cancer
Loading metrics Open Access Peer-reviewed Research Article Abstract Breast cancer is heterogenous in development and cell population with prognoses being highly dependent on numerous factors from driving mutations, biomarker expression and variation in extracellular environment, all affecting response to therapies.
BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with age
Adeniji O.S. Giron L.B. Purwar M. Zilberstein N.F. Kulkarni A.J. Shaikh M.W. Balk R.A. Moy J.N. Forsyth C.B. Liu Q. et al. COVID-19 severity is associated with differential antibody Fc-mediated innate immune functions. mBio. 2021; 12 ()https://doi.org/10.1128/mbio.00281-21 Altarawneh H.N. Chemaitelly H. Ayoub H.H. Tang P. Hasan M.R. Yassine H.M. Al-Khatib H.A. Smatti M.K. Coyle P. Al-Kanaani Z. et al. Effects of previous infection and vaccination on symptomatic Omicron infections. N. Engl. J. Med.
BNT162b2 induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with age
Abstract Each novel SARS-CoV-2 variant renews concerns about decreased vaccine efficacy caused by evasion of vaccine induced neutralizing antibodies. However, accumulating epidemiological data show that while vaccine prevention of infection varies, protection from severe disease and death remains high. Thus, immune responses beyond neutralization could contribute to vaccine efficacy.
Alterations in Immune Response Profile of Tumor-Draining Lymph Nodes after High-Intensity Focused Ultrasound Ablation of Breast Cancer Patients
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.
GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation
Highlights • GATA6-AS1 is a lncRNA highly expressed in human endoderm with two isoforms • GATA6-AS1 controls human endoderm differentiation through regulating GATA6 • GATA6-AS1 regulates GATA6, the functional target in endoderm differentiation • GATA6-AS1 is required for SMAD2/3-mediated GATA6 transcriptional activation Summary Transcriptome analysis has uncovered a series of long noncoding RNAs (lncRNAs) transcribed during cell differentiation, but how lncRNA is integrated with known...
Association of ω with the C-terminal region of β' subunit is essential for assembly of RNA polymerase in Mycobacterium tuberculosis
The ω subunit is the smallest subunit of bacterial RNA polymerase (RNAP). Although homologs of ω are essential in both eukaryotes and archaea, this subunit has been known to be dispensable for RNAP in Escherichia coli (Eco) and in other bacteria. In this study, we characterized an indispensable role of the ω subunit in Mycobacterium tuberculosis (Mtb). Unlike the well-studied Eco RNAP, the Mtb RNAP core enzyme cannot be functionally assembled in the absence of the ω subunit.
Association of ω with the C-Terminal Region of the β′ Subunit Is Essential for Assembly of RNA Polymerase in Mycobacterium tuberculosis
The ω subunit is the smallest subunit of bacterial RNA polymerase (RNAP). Although homologs of ω are essential in both eukaryotes and archaea, this subunit has been known to be dispensable for RNAP in Escherichia coli and in other bacteria. In this study, we characterized an indispensable role of the ω subunit in Mycobacterium tuberculosis. Unlike the well-studied E. coli RNAP, the M. tuberculosis RNAP core enzyme cannot be functionally assembled in the absence of the ω subunit.
A reusable material with high performance for removing NO at room temperature: its performance, mechanism and kinetics
Up to now, it is a very challenging work to purify NO by a reusable sample at room temperature. In this study, series materials of urea-MnOx/ACF and urea-xCeO2-(1-x)MnO2/ACF were prepared used for purifying NO at room temperature for the first time. The experimental results showed that 10%urea-8%(0.5CeO2-0.5MnO2)/ACF could yield the highest NO conversion among all of the prepared samples, which showed an above 90% NO conversion ratio with 1000 ppm NO in the initial mixed gases.
A reusable material with high performance for removing NO at room temperature: performance, mechanism and kinetics
Removing NO from the air with a reusable material at room temperature is challenging. In this study, a series of urea–MnO /ACF and urea–x(CeO –(1 − x)MnO )/ACF materials were prepared and used for removing NO at room temperature. The results showed that 10% urea–8% (0.5CeO –0.5MnO )/ACF yielded the highest NO conversion, which showed an NO conversion ratio above 90% with 1000 ppm NO in the initial mixed gases.
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