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Peng-Ying Chen

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Articles

Interpretative Letter Issued for Subparagraph 4 of Paragraph 1 of Article 146-1 of Insurance Act

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By Trisha Chang, Peng-Ying Chen, Sherry XR Guo
| Lexology Verified
The Financial Supervisory Commission issued the interpretative letter for Subparagraph 4 of Paragraph 1 of Article 146-1 of the Insurance Act, Ref. No. Jin-Guan-Bao-Tsai-Zi No. 11004934441 dated September 16, 2021, and abolished the letter issued by the Ministry of Finance, Ref. No. Tai-Tsai-Bao-Zi No. 0900707707 dated September 10, 2001.
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Impacts of L1 Promoter Variation and L2 Clavulanate Susceptibility on Ticarcillin-Clavulanate Susceptibility of Stenotrophomonas maltophilia

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By Hsin-Hui Huang, Peng-Ying Chen, Yi-Tsung Lin, Rouh-Mei Hu
| asm.org
ABSTRACTInducible expression of L1 and L2 β-lactamases is the principal mechanism responsible for β-lactam resistance in Stenotrophomonas maltophilia. Ticarcillin-clavulanate (TIM) is one of the few effective β-lactams for S. maltophilia treatment. Clavulanate (CA) is a β-lactamase inhibitor that specifically targets class A, C, and D β-lactamases. In view of the presence of class B L1 β-lactamase, it is of interest to elucidate why TIM is valid for S. maltophilia treatment.
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ClpA and HtpX Proteases Are Involved in Intrinsic Aminoglycoside Resistance of Stenotrophomonas maltophilia and Are Potential Aminoglycoside Adjuvant Targets

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By Hsin-Hui Huang, Yi-Tsung Lin, Li-Hua Li, Peng-Ying Chen
| American Society for Microbiology (ASM)
The linkage of the protease-chaperon system, SmeYZ pump, and aminoglycoside resistance was assessed in Stenotrophomonas maltophilia. The clpA, clpS, clpP, and htpX genes were upregulated in response to kanamycin exposure. Of these, clpA and htpX were the primary determinants responsible for intrinsic aminoglycoside (AG) resistance.
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