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Pengbin Yin on Muck Rack

Pengbin Yin

As seen in: Nature, Wiley Online Library, Royal Society of Chemistry, Cell Press, Journal of the American Society of Nephrology (JASN)
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Articles

The p75 neurotrophin receptor controls the skeletal stem cell niche through sensory innervation

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By Zuoxing Wu, Zhengqiong Luo, Zihan Chen, Xuemei He, Fan Shi, Jie Han, Haitao Huang, Baohong Shi, Long Zhang, Yu Li, Junmin Shen, Seoyeon Bok, Jun Sun, Xing Niu, Ke Mo, Pengbin Yin, Lige Leng, Xin Wang, Jie Zhang, Lanfen Chen, Dawang Zhou, Weinan Cheng, Jianmin Huang, Matthew Greenblatt, Ren Xu
| Cell Press Verified
Keywords skeletal stem cell niche osteogenesis innervation p75NTR Alzheimer’s disease Get full text access Log in, subscribe or purchase for full access. References 1. Bliuc, D. ∙ Tran, T. ∙ Adachi, J.D. ... Cognitive decline is associated with an accelerated rate of bone loss and increased fracture risk in women: a prospective study from the Canadian Multicentre Osteoporosis Study J. Bone Miner. Res. 2021; 36:2106-2115 2. Ruggiero, C. ∙ Baroni, M. ∙ Xenos, D. ...
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Bifidobacterium animalis subsp. lactis A6 ameliorates bone and muscle loss via modulating gut microbiota composition and enhancing butyrate production | Bone Research

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By Pengbin Yin
| Nature Verified
Abstract Systematic bone and muscle loss is a complex metabolic disease, which is frequently linked to gut dysfunction, yet its etiology and treatment remain elusive. While probiotics show promise in managing diseases through microbiome modulation, their therapeutic impact on gut dysfunction-induced bone and muscle loss remains to be elucidated.
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Spermidine-eIF5A axis is essential for muscle stem cell activation via translational control - Cell Discovery

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By Pengbin Yin, DaHai Zhu, Yong Zhang
| Nature Verified
Abstract Adult skeletal muscle stem cells, also known satellite cells (SCs), are quiescent and activate in response to injury. However, the activation mechanisms of quiescent SCs (QSCs) remain largely unknown. Here, we investigated the metabolic regulation of SC activation by identifying regulatory metabolites that promote SC activation. Using targeted metabolomics, we found that spermidine acts as a regulatory metabolite to promote SC activation and muscle regeneration in mice.
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