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Pengyuan Hu

As seen in: Nature, TechNode
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Articles

PFKM acts as a metabolic switch initiating donut-shaped mitochondrial remodeling to promote osteogenesis

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By Nengwen Huang, Jie Lu, Yifeng Xing, Weiping Chen, Kaidi Chen, Pengyuan Hu, Kaixun He, Wenxiu Yuan, Yuwei Zhou, Junjin Lin, Sihui Zhang, Yanjing Ou, Jiang Chen, Geyuan Zheng, Hanyu Lin, Zhenzhu Xue
| Nature Verified
Abstract Osteogenic differentiation requires sophisticated mitochondrial adaptation to meet bioenergetic demands, yet regulatory checkpoints governing this organelle reorganization remain poorly defined. Through single-cell RNA sequencing reanalysis and metabolic intervention, this study unveils a non-canonical signaling role for PFKM, traditionally recognized solely as a glycolytic enzyme, in orchestrating mitochondrial remodeling during bone formation.
Open in Who Shared Issue with article?

Chinese youths find romance in AI chatbots · TechNode

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By Pengyuan Hu, Qin Chen
| TechNode Verified
Editor’s note: All interviewees quoted in the article use pseudonyms for privacy reasons. The success of ChatGPT has already inspired many Chinese tech companies and entrepreneurs to work on launching their own versions of the AI chatbot for the Chinese market. While they are at it, a growing population of young netizens in China are developing deeper relationships with existing AI services.
Open in Who Shared Issue with article?
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