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Peter Androvic

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Articles

Decoding the Transcriptional Response to Ischemic Stroke in Young and Aged Mouse Brain

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By Czech Republic, Peter Androvic, Denisa Kirdajova, Jana Tureckova
| Cell Reports Verified
Highlights • RNA-seq analysis of aging, ischemic stroke, and their interaction in female mice • Response to stroke in young and aged brain is similar, but differs in magnitude • Aged ischemic brain is characterized by upregulation of type-I interferon signaling • Aged mice downregulate axonal and synaptic maintenance program after stroke Summary Ischemic stroke is a well-recognized disease of aging, yet it is unclear how the age-dependent vulnerability occurs and what are the underlying...
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