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Articles by Peter Arvan
SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells - Nature Communications
Abstract Proteolytic cleavage of proglucagon by prohormone convertase 2 (PC2) is required for islet α cells to generate glucagon. However, the regulatory mechanisms underlying this process remain largely unclear.
Autophagy of the ER: the secretome finds the lysosome
ATZ α-1-antitrypsin variant Z DENV Dengue virus EBV Ebola virus ER endoplasmic reticulum ERAA ER-associated autophagy ERAD ER-associated degradation ERES ER exit sites ERGIC ER-golgi intermediate compartment ERLAD ER-to-lysosome-associated degradation ER-phagy ER-coupled autophagy ESCC esophageal squamous cell carcinoma FMDV foot-and-mouth disease virus GIM GABARAP interaction motif HSAN II hereditary sensory and autonomic neuropathy type II IDR intrinsically disordered region JEV Japanese...
Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction - Nature Communications
Abstract Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer protein alpha (PITPNA) stimulates activity of phosphatidylinositol (PtdIns) 4-OH kinase to produce sufficient PtdIns-4-phosphate (PtdIns-4-P) in the trans-Golgi network to promote insulin granule maturation. PITPNA in beta-cells of T2D human subjects is markedly reduced suggesting its depletion accompanies beta-cell dysfunction.
Simultaneous Measurement of Changes in Mitochondrial and Endoplasmic Reticulum Free Calcium in Pancreatic Beta Cells
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The role of thyroglobulin in thyroid hormonogenesis
Abstract In humans, the thyroid hormones T3 and T4 are synthesized in the thyroid gland in a process that crucially involves the iodoglycoprotein thyroglobulin. The overall structure of thyroglobulin is conserved in all vertebrates.
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