Skip To Main Content
Sebastian Barg on Muck Rack

Sebastian Barg

As seen in: Nature, Cell Reports, Diabetes Magazine
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Sebastian

Contact Sebastian, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Highly adaptable deep-learning platform for automated detection and analysis of vesicle exocytosis - Nature Communications

|
By Hsin-Fang Chang, Omnia M Khamis, Nadia Alawar, Santiago Echeverry, James Daniel, Peter Lipp, Eugenio F. Fornasiero, Salvatore Valitutti, Sebastian Barg, Constantin Pape, Ali H. Shaib
| Nature Verified
Abstract Activity recognition in live-cell imaging is labor-intensive and requires significant human effort. Existing automated analysis tools are largely limited in versatility. We present the Intelligent Vesicle Exocytosis Analysis (IVEA) platform, an ImageJ plugin for automated, reliable analysis of fluorescence-labeled vesicle fusion events and other burst-like activity.
Open in Who Shared Issue with article?

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction - Nature Communications

|
By Anoop Arunagiri, Amaury Cazenave-Gassiot, Adhideb Ghosh, Ferdinand von Meyenn, Shiqi Jia, Peter Arvan, Sebastian Barg, Vytas A. Bankaitis
| Nature Verified
Abstract Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol transfer protein alpha (PITPNA) stimulates activity of phosphatidylinositol (PtdIns) 4-OH kinase to produce sufficient PtdIns-4-phosphate (PtdIns-4-P) in the trans-Golgi network to promote insulin granule maturation. PITPNA in beta-cells of T2D human subjects is markedly reduced suggesting its depletion accompanies beta-cell dysfunction.
Open in Who Shared Issue with article?

Local PI(4,5)P2 signaling inhibits fusion pore expansion during exocytosis

|
By Muhmmad Omar-Hmeadi, Sebastian Barg
| Cell Reports Verified
Highlights • PI(4,5)P2 accumulates acutely at the release site during regulated exocytosis • Local PI(4,5)P2 transients recruit endocytosis proteins and constrict fusion pore expansion • Interfering with PI(4,5)P2 synthesis accelerates fusion pore expansion and peptide release Summary Phosphatidylinositol(4,5)bisphosphate (PI(4,5)P2) is an important signaling phospholipid that is required for regulated exocytosis and some forms of endocytosis.
Open in Who Shared Issue with article?
See all 6 articles