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Adhideb Ghosh

As seen in: Nature, Wiley Online Library, MDPI, Genome Biology, Science Magazine, BioRxiv, Cell Metabolism, Cell Press, Stem Cell Reports, WARC and
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Articles

DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function

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By Anand Sharma, Radhika Khandelwal, Jelena Zurkovic, Fen Long, Tongtong Wang, Revati S Dewal, Chunyan Wu, Adhideb Ghosh, Klug Manuel, Alaa Othman, Chandramohan Chitraju, Robert V. Farese, Tobias C. Walther, Miroslav Balaz, Christoph Thiele, Christian Wolfrum
| Cell Metabolism Verified
Main text (Cell Metabolism 38, 1154–1171.e1–e7; June 2, 2026) After manuscript revision, the International Indirect Calorimetry Consensus Committee (IICCC) established new guidelines for analysis of indirect calorimetry (10.1038/s42255-025-01360-4), emphasizing the use of metabolic rates and ANCOVA not normalized to body weight.
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DGAT-driven futile lipid cycling has a pronounced, yet concealed, thermogenic function

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By Anand Sharma, Radhika Khandelwal, Jelena Zurkovic, Fen Long, Tongtong Wang, Revati S Dewal, Chunyan Wu, Adhideb Ghosh, Alaa Othman, Chandramohan Chitraju, Robert V. Farese, Tobias C. Walther, Miroslav Balaz, Christoph Thiele, Christian Wolfrum, Klug Manuel
| Cell Metabolism Verified
Keywords futile cycles thermogenesis DGAT futile lipid cycling AMPK energy homeostasis shivering thermal homeostasis lipid metabolism adipose tissue Introduction Maintenance of body temperature is an essential homeostatic mechanism.1 Human infants utilize UCP1-dependent thermogenesis (UDT), while adults progressively lose UCP1 and thus may extensively rely on alternative UCP1-independent thermogenesis (UIT) mechanisms.2,3,4 Rodents utilize brown adipose tissue UDT to maintain euthermia during...
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MEDAG functions as an A-kinase-anchoring protein in adipocytes

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By Fen Long, Adhideb Ghosh, Tianyu Xu, Lianggong Ding, Chunyan Wu, Radhika Khandelwal, Falko Noé, Wenfei Sun, Hua Dong, Tongtong Wang, Anne H. Hoffmann, Vincent Gardeux, Bart Deplancke, Laith Abu-Nawwas, Patrik Stefanicka, Lukas Varga, Jonatan R. Ruiz, Matthias Blüher, Miroslav Balaz, Anand Sharma, Christian Wolfrum
| Cell Press Verified
Clinical transcriptome study cohorts For human cohort 1, Adipose tissue samples were immediately cleaned from blood and connective tissue, and frozen in liquid nitrogen until further processing. rRNA-depleted RNA-sequencing data were prepared on the basis of the SMARTseq protocol.61 Briefly, isolated RNA was treated with DNaseI and reverse transcribed using an oligo(dT) and a template switch oligo.
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