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Articles by Peter Brazda
A longitudinal single-cell atlas to predict outcome and toxicity after BCMA-directed CAR T cell therapy in multiple myeloma
Results We recruited a real-world cohort of 61 RRMM patients treated with BCMA-directed CAR T cells at our center. Samples of 57 patients were available for single-cell multi-omics profiling: A total of 135 peripheral blood mononuclear cell (PBMC) samples at 3 different time points were collected for single cell RNA, B cell receptor (BCR), TCR and surface protein profiling.
Podocalyxin and ciliary neurotrophic factor receptor are novel components of the surfaceome of chondrogenic cells
Abstract Chondrogenesis, the process driving cartilage formation, is critical for advancing strategies in cartilage repair and mitigating osteoarthritis (OA) management. In this study, we present the first comprehensive quantitative analysis of the surfaceome of chondrogenic cells using a well-established in vitro chondrogenic model.
Sensitivity to Vγ9Vδ2TCR T cells is imprinted after single mutations during early oncogenesis
Abstract Vγ9Vδ2T cells have the unique ability to recognize a broad range of malignant transformed cells. The tumor targeting event involving BTN2A1 and BTN3A1 dimers on the tumor cell surface is critical, leading to full activation of the TCR.
Antiviral responses induced by Tdap-IPV vaccination are associated with persistent humoral immunity to Bordetella pertussis - Nature Communications
Abstract Many countries continue to experience pertussis epidemics despite widespread vaccination. Waning protection after booster vaccination has highlighted the need for a better understanding of the immunological factors that promote durable protection. Here we apply systems vaccinology to investigate antibody responses in adolescents in the Netherlands (N = 14; NL) and the United Kingdom (N = 12; UK) receiving a tetanus-diphtheria-acellular pertussis-inactivated poliovirus (Tdap-IPV) vaccine.
Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells - Nature Immunology
Abstract Few cancers can be targeted efficiently by engineered T cell strategies. Here, we show that γδ T cell antigen receptor (γδ TCR)-mediated cancer metabolome targeting can be combined with targeting of cancer-associated stress antigens (such as NKG2D ligands or CD277) through the addition of chimeric co-receptors.
Agonist-controlled competition of RAR and VDR nuclear receptors for heterodimerization with RXR is manifested in their DNA-binding
Heterodimerization between EGFP-VDR and mScarlet3-RXR was monitored by Förster resonance energy transfer (FRET). FRET is the non-radiative transfer of energy from an excited donor dye (here, EGFP) to a nearby acceptor (mScarlet3) via dipole-dipole coupling.
Uncovering the mode of action of engineered T cells in patient cancer organoids - Nature Biotechnology
Abstract Extending the success of cellular immunotherapies against blood cancers to the realm of solid tumors will require improved in vitro models that reveal therapeutic modes of action at the molecular level. Here we describe a system, called BEHAV3D, developed to study the dynamic interactions of immune cells and patient cancer organoids by means of imaging and transcriptomics.
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