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Articles

Distinct genomic and immunologic tumor evolution in germline TP53- driven breast cancers

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By Nabamita Boruah, David Chiujoshua Hoyos, Renyta Moses, Ryan Hausler, Heena Desai, Anh Le, Madeline Whitaker Good, Gregory Kelly, Abigail Doucette, Peter Gabriel, Michael Feldman, Kurt A. Schalper, Shari Goldfarb, Anupma Nayak, Arnold J. Levine, Benjamin D. Greenbaum, Kara Maxwell, Ashvathi Raghavakaimal, Maliha Tayeb, Mohana Narasimhamurthy, Miguel Lopez de Rodas
| Nature Verified
Abstract Pathogenic germline TP53 alterations cause Li-Fraumeni Syndrome (LFS), and breast cancer (BC) is the most common cancer in LFS females. Here, we perform a multimodal analysis, comparing LFS-BC with sporadic premenopausal breast cancer which shows that nearly all LFS-BC undergo biallelic loss of TP53, with no recurrent oncogenic variants except ERBB2 (HER2) amplification. Compared to sporadic BC, in situ and invasive LFS-BC exhibit a high burden of short amplified aneuploid segments.
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460 LYNCH SYNDROME CARRIERS HAVE SIMILAR PREVALENCE OF IBD BUT LOWER OVERALL PREVALENCE OF AUTOIMMUNE DISEASES COMPARED TO CONTROLS

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By Grace Gong, Michaela E Dungan, Peter Gabriel
| Gastrointestinal Endoscopy Verified
Also available on ScienceDirect
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Über 1.000 Prominente stehen hinter Israel

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By Roger Waters, Peter Gabriel, Helen Mirren
| eXXpress
ESC: Über 1.000 Stars unterstützen Israel Am Mittwoch wurde eine Petition bekannt, in der über 1.100 Musiker – darunter Pink-Floyd-Mitbegründer Roger Waters, Peter Gabriel und die britische Band Mass...
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