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Articles by Peter Ganz
Cross-ancestry comparison of aptamer and antibody protein measures - Nature Communications
Abstract Measures from affinity-proteomics platforms often correlate poorly, challenging interpretation of protein associations with genetic variants and phenotypes. Here, we examine 2157 proteins measured on both SomaScan 7k and Olink Explore 3072 across 1930 participants with genetic similarity to European, African, East Asian, and Admixed American ancestry references. Inter-platform correlation coefficients for these 2157 proteins follow a bimodal distribution (median r = 0.30).
Proteome-wide association study of prostate cancer risk across populations - Nature Communications
Abstract There is insufficient understanding of the molecular basis of prostate cancer (PCa) across different populations. We perform a large-scale proteome-wide association study (PWAS) to identify proteins with genetically regulated expression in plasma to be associated with PCa risk across populations.
Risk factors for mortality in patients with kidney failure on hemodialysis identified by proteomic analysis of CRIC and PACE studies - Nature Communications
Abstract More than 50% of patients with kidney failure undergoing maintenance hemodialysis die within 5 years, a fate unexplained by traditional risk factors. To identify biological risk factors, we analyze 6287 circulating proteins and mortality in 893 participants undergoing hemodialysis in the Chronic Renal Insufficiency Cohort (CRIC) and Predictors of Arrhythmic and Cardiovascular Risk in End-Stage Renal Disease (PACE) studies.
Human plasma proteomic profile of clonal hematopoiesis - Nature Communications
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Abstract Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer insights into downstream clinical consequences. Here we explore these patterns in clonal hematopoiesis of indeterminate potential (CHIP), which is linked to several cancer and non-cancer outcomes, including coronary artery disease (CAD).
By Zhi Yu, Amélie Vromman, Art Schuermans, Tetsushi Nakao, Mesbah Uddin, Abhishek Niroula, Gabriel K. Griffin, Michael C. Honigberg, Christopher Gibson, Daniel Katz, Usman Tahir, Jacqueline S. Dron, Michael Pan, Shriienidhie Ganesh, Joshua Weinstock, Ramachandran S. Vasan, Gina M. Peloso, Peter Ganz, JoAnn E. Manson, Joann Manson, Bernhard Haring, Charles Kooperberg, Joshua C. Bis, Bruce M. Psaty, Yuan-I Min, Adolfo Correa, Jerome I. Rotter, Stephen S. Rich, Benjamin Ebert, Bing Yu, Christie M. Ballantyne, Josef Coresh, Vijay Sankaran, Alexander Bick, Siddhartha Jaiswal, Robert Gerszten, NHLBI Trans-Omics, Peter Libby, Rajat Gupta
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Nature
Verified
Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia - Communications Medicine
Abstract Biological age can be quantified by composite proteomic scores, called proteomics-based aging clocks (PACs). We investigated whether a discrepancy between chronological and biological age in midlife and late-life is associated with cognition and dementia risk. We used two longitudinal population-based studies: the Atherosclerosis Risk in Communities (ARIC) Study and the Multi-Ethnic Study of Atherosclerosis (MESA).
Proteomics of CKD progression in the chronic renal insufficiency cohort - Nature Communications
Abstract Progression of chronic kidney disease (CKD) portends myriad complications, including kidney failure. In this study, we analyze associations of 4638 plasma proteins among 3235 participants of the Chronic Renal Insufficiency Cohort Study with the primary outcome of 50% decline in estimated glomerular filtration rate or kidney failure over 10 years. We validate key findings in the Atherosclerosis Risk in the Communities study.
Efficacy of Continuous Transdermal Nitroglycerin for Treating Hot Flashes by Inducing Nitrate Cross-tolerance in Perimenopausal and Postmenopausal Women: A Randomized Clinical Trial | Gynecology | JAMA Internal Medicine | JAMA Network
Efficacy of Continuous Transdermal Nitroglycerin for Treating Hot Flashes by Inducing Nitrate Cross-tolerance in Perimenopausal and Postmenopausal Women: A Randomized Clinical Trial Audio (14:14) 0:00 / 0:00 Key Points Question Does uninterrupted transdermal nitroglycerin therapy decrease the frequency and severity of menopause-related hot flashes?
The Liquid Health Check: How Proteomics Can Transform Healthcare
A blood test is an important step toward making almost any medical diagnosis. This is true whether there is concern that a patient may have diabetes, kidney disease, heart failure or many other conditions. Most of the time, these blood tests deliver a single piece of information. They provide one clue about a potential health risk. Additional blood tests and specialized tests, such as ultrasound, X-rays or stress testing, are needed to get to the working diagnosis.
Emerging Affinity Reagents for High Throughput Proteomics
High throughput proteomic profiling of human plasma is immensely challenging due to the extraordinary complexity and broad dynamic range of plasma protein concentrations. Mass spectrometry is unmatched for its ability to provide unambiguous identification of specific peptides, though its application to plasma proteomics at the population level remains prohibitive due to slow throughput and inability to quantify low abundant proteins without extensive upfront sample separation.
William Ganz and His Legacy
TO THE EDITOR: We read with interest the historical review “Swan, Ganz, and Their Catheter: Its Evolution Over the Past Half Century” (1). As William Ganz's sons, we witnessed his professional career in Czechoslovakia and later in the United States and his role in the development of the catheter that bears his name. We started our respective careers as an interventional cardiologist (Peter) and an intensivist (Tomas) at a time when the Swan–Ganz catheter became widely used.
Association of Osteopontin, Neopterin, and Myeloperoxidase With Stroke Risk in Patients With Prior Stroke or Transient Ischemic Attacks
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Development and Validation of a Protein-Based Risk Score for Cardiovascular Outcomes Among Patients With Stable Coronary Heart Disease
Importance Precise stratification of cardiovascular risk in patients with coronary heart disease (CHD) is needed to inform treatment decisions. Objective To derive and validate a score to predict risk of cardiovascular outcomes among patients with CHD, using large-scale analysis of circulating proteins. Design, Setting, and Participants Prospective cohort study of participants with stable CHD.
HIV and Hepatitis C-Coinfected Patients Have Lower Low‐Density Lipoprotein Cholesterol Despite Higher Proprotein Convertase Subtilisin Kexin 9 (PCSK9): An Apparent “PCSK9-Lipid Paradox”
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Methods and Results We studied 567 participants from a clinic‐based cohort to compare PCSK9 levels in patients with HIV/HCV coinfection (n=110) with those with HIV infection alone (n=385) and with uninfected controls (n=72). The mean age was 49 years, and the median LDL‐C level was 100 mg/dL (IQR 77–124 mg/dL); 21% were taking statins. The 3 groups had similar rates of traditional risk factors.
By Payal Kohli, Peter Ganz, Yifei Ma, Rebecca Scherzer, Steven Deeks, Scott Wasserman, Rob Scott Verified, Sophia Hur, Bernard Weigel, Carl Grunfeld
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jaha.ahajournals.org
Traditional Risk Factors Versus Biomarkers for Prediction of Secondary Events in Patients With Stable Coronary Heart Disease: From the Heart and Soul Study
Background Patients with stable coronary heart disease (CHD) have widely varying prognoses and treatment options. Validated models for risk stratification of patients with CHD are needed. We sought to evaluate traditional and novel risk factors as predictors of secondary cardiovascular (CV) events, and to develop a prediction model that could be used to risk stratify patients with stable CHD.
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