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ArticleOnline now102988Open access Affiliations & Notes 1Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, 10065, United States of America 2Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia 3Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland 4Bioinformatics Resource Center, The Rockefeller University, New York, NY, 10065, United States of America 5Weill Cornell Medical...
Abstract Measures from affinity-proteomics platforms often correlate poorly, challenging interpretation of protein associations with genetic variants and phenotypes. Here, we examine 2157 proteins measured on both SomaScan 7k and Olink Explore 3072 across 1930 participants with genetic similarity to European, African, East Asian, and Admixed American ancestry references. Inter-platform correlation coefficients for these 2157 proteins follow a bimodal distribution (median r = 0.30).
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