Peter Hwang

Keywords spatial transcriptomics single-cell nasal epithelium inflammation chronic rhinosinusitis remodeling autoimmunity nasal polyp type 2 inflammation Introduction Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease of the nasal and sinonasal cavities.

Keywords efflux pump Acinetobacter baumannii multidrug resistance AdeG cryoelectron microscopy Get full text access Log in, subscribe or purchase for full access. References 1. De Oliveira, D.M.P. ∙ Forde, B.M. ∙ Kidd, T.J. ... Antimicrobial Resistance in ESKAPE Pathogens Clin. Microbiol. Rev. 2020; 33, e00181-19 2. Sarshar, M. ∙ Behzadi, P. ∙ Scribano, D. ... Acinetobacter baumannii: An Ancient Commensal with Weapons of a Pathogen Pathogens. 2021; 10, 387 3. Tacconelli, E. ∙ Carrara, E. ∙ Savoldi, A. ...

Abstract Neuromyelitis Optica (NMO) is an autoimmune disease of the central nervous system where pathogenic autoantibodies target the human astrocyte water channel aquaporin-4 causing neurological impairment. Autoantibody binding leads to complement dependent and complement independent cytotoxicity, ultimately resulting in astrocyte death, demyelination, and neuronal loss. Aquaporin-4 assembles in astrocyte plasma membranes as symmetric tetramers or as arrays of tetramers.