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Articles by Peter McHugh
CDIN1-Codanin-1 complex defective in congenital dyserythropoietic anaemia type I is an RNA nuclease
Abstract Congenital Dyserythropoietic Anaemia type I (CDA-I) is a rare inherited disorder of erythropoiesis, in which erythroid cells display a unique nuclear phenotype referred to as ‘spongy’ heterochromatin. The molecular basis of CDA-I remains unknown, with most cases of CDA-I caused by mutations in CDAN1, encoding Codanin-1, or CDIN1, encoding for Codanin-1-interacting nuclease 1 (CDIN1).
DNA repair drives cisplatin-induced neuronal death
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PCR confirmation of gene knockout in mice Genomic DNA was isolated from tails and CRISPR target sites were amplified by polymerase chain reaction. For PCR of the Xpa gene, the following primers were used: Forward, 5’-ACTGCCTCGCCCTTCATAGG-3’, Reverse, 5’-CTACCCCACCAGACACCACT-3’, Internal, 5’-AGCTCTGCACCATAGACGTG-3’. For PCR of the Xpc gene, the following primers were used: Forward, 5’-GATCTACGTCGTCCGCCATG-3’, Reverse, 5’-GTTGGGTCTTGGAAGCACTC-3’, Internal, 5’-TCCCTCCGTCTTGGTTTTGG-3’.
By William Nathan, Chuanyuan Chen, Rosy Sakr, Bruno Siqueira Mietto, Vincent van Batenburg, Jeroen van den Berg, Josette J Wlaschin, Ferenc Livak, Elsa Callen, Nancy Wong, Eliza Lloyd, Hanna Silberberg, Sushma Sharma, Raj Chari, Tzipporah Freeman, Baek Kim, Alexander van Oudenaarden, Alexander T Chesler, Michael Ward, Lisa D. Boxer, Peter McHugh, Andrei Chabes, Claire Le Pichon, André Nussenzweig
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Cell Press
Verified
OPINION: Value our vibrant local library, support Scappoose levy - Columbia County Spotlight
In support of the Scappoose Public Library, I’m voting yes for Measure 5-308. I’ve been a patron of the Scappoose Public Library for almost 50 years. It has always served our community well, but never better than it does today. Here’s a few of the many reasons that I can say that. Our library circulation is more than 30% greater than any other library in Columbia County. The library is open 51 hours a week and at times when it will get the most usage.
‘I Was Wrong About Charlie Kirk’: Six Conservative Students on His Killing
Let’s be honest about Charlie Kirk’s life — and death We can hold two thoughts in our head at the same time. In the days since the killing of right-wing activist Charlie Kirk, the overwhelming response on the left has been shock and horror. No one of prominence has justified the killing; hundreds, from Democratic Party leadership on down, have …
Opinion | ‘I Was Wrong About Charlie Kirk’: Six Conservative Students on His Killing
Today’s college conservatives grew up in Charlie Kirk’s Republican Party — watching his “prove me wrong” videos, following his social media campaigns or debating his often-controversial views when he came to campus. Times Opinion turned to some of them to understand how they are grappling with the killing of the campus conservative movement’s ubiquitous star.
Who is Tim Walz? Meet Harris’s pick for vice president
Vice President Kamala Harris has picked Gov. Tim Walz (D-MN) to be her running mate for the 2024 presidential election. Upon announcing her campaign, Walz quickly endorsed Harris, keeping vice presidential buzz to a minimum while many of his Midwestern colleagues nudged his name into the fold. He became a favorite, alongside Gov. Josh Shapiro (D-PA), in the final days before her decision became public.
Who is Pete Buttigieg? Meet one of the six top names on Harris’s VP short list
Welcome to NewsBreak, an open platform where diverse perspectives converge. Most of our content comes from established publications and journalists, as well as from our extensive network of tens of thousands of creators who contribute to our platform. We empower individuals to share insightful viewpoints through short posts and comments.
Who is Tim Walz? Meet the potential VP for Kamala Harris
With President Joe Biden bowing out of the race less than four months before Election Day, attention has shifted toward presumed nominee and Vice President Kamala Harris. In the aftermath, many notable Democrats, including former Speaker Nancy Pelosi (D-CA), have endorsed her bid to be commander in chief. Others have inched close to her side, hoping to be her running mate. Gov. Tim Walz (D-MN) has recently surfaced in Democratic circles as a potential companion to a Harris presidential ticket.
Who is Tim Walz? Meet one of the six top names on Harris’s VP short list
Welcome to NewsBreak, an open platform where diverse perspectives converge. Most of our content comes from established publications and journalists, as well as from our extensive network of tens of thousands of creators who contribute to our platform. We empower individuals to share insightful viewpoints through short posts and comments.
Secret Service view of shooter may have been obstructed Original
As questions swirl over the delayed response to former President Donald Trump’s attempted assassination, new analysis from the Washington Post supposes trees and the sloped barn roof Thomas Matthew Crooks fired from may have obstructed the view of countersnipers. Using satellite imagery and over 40 photos and videos, the Washington Post developed a 3D model mapping out the shooting site and positions of its key players.
Police snipers were stationed in same building as Trump shooter
A team of snipers, tasked with protecting former President Donald Trump, were perched just below the roof where Thomas Matthew Crooks fired off multiple shots into the crowd. According to a source familiar with the investigation, CNN reported that a unit made up of local law enforcement snipers had been assigned to the second floor of the warehouse, approximately 410 feet from Trump’s podium. Supervisors had instructed them to monitor the crowd.
Trump Rally Shooter Described as “lonely” and “sweet” by those who knew him
Welcome to NewsBreak, an open platform where diverse perspectives converge. Most of our content comes from established publications and journalists, as well as from our extensive network of tens of thousands of creators who contribute to our platform. We empower individuals to share insightful viewpoints through short posts and comments.
Profiling Trump's Shooter- Washington Examiner
Thomas Matthew Crooks, the FBI’s sole suspect in Trump’s attempted assassination, was 20 years old when he was seen climbing on to a roof and aiming his father’s rifle at the former president. As investigators search for a motive, those who knew him best attempt to reconcile with their shock. Crooks, who the Secret Service killed at the scene, hailed from Bethel Park, Pennsylvania, just an hour and a half drive from Butler, where the shooting took place.
Jill Biden spoke with Melania Trump after assassination attempt on former president
First lady Jill Biden reportedly spoke to former first lady Melania Trump on the phone in the wake of the assassination attempt on former President Donald Trump. Reports of the two women speaking surfaced Monday, though it’s not clear exactly what was said. Relieved that her husband is safe, Melania Trump expressed in a statement Sunday that she is “grateful to the brave secret service agents and law enforcement officials who risked their lives” protecting him.
Michigan's bird flu response unsettles residents
Michigan has launched a comprehensive response to rising bird flu cases across the state, leaving many of its dairy farmers fearful of the impacts on their businesses. Increasingly strict regulations have blanketed some of the state’s small towns as it attempts to contain cases in cattle and humans that have spiked in recent months, according to Reuters.
Prosecutors anticipate Harvey Weinstein retrial as new victims surface
Harvey Weinstein appeared before a Manhattan criminal court Tuesday as prosecutors pursue new sexual assault allegations and a likely retrial for the former producer. “We believe the defendant forcibly raped and sexually abused women in Manhattan that fall within the statute of limitations,” Nicole Blumberg, the assistant district attorney, said. “There were women in 2020 who were not ready to proceed with the legal process.
Lawmakers reconsider mask bans after spring, campus protests
In the wake of the spring’s violent campus protests, state and local politicians from both sides of the aisle have considered cracking down on face coverings, once required in all classrooms. Officials in Los Angeles and New York have recently floated the idea of banning masks in their cities, attempting to deter violent protesters who, lawmakers say, often wore coverings to conceal their identities.
Congress launches bipartisan effort against explicit AI deepfakes Original
A group of bipartisan lawmakers has introduced legislation aimed at combating the horde of websites distributing nonconsensual, sexually explicit deepfakes. Over the last few months, Republicans and Democrats have floated multiple bills that would hold parties accountable for the distribution of deepfake pornography, as well as give victims the ability to seek financial settlement.
How to safely and legally use fireworks this Fourth of July
Independence Day is nearly here, hot dogs are being prepped, and people are sporting their best red, white, and blue. In addition to the annual parades, marching bands, and afternoon barbecues, many people will be stopping by the red-and-white-striped fireworks tents set up outside the Walmarts and roadside turnoffs of the United States.
How to use fireworks safely and legally this Fourth of July
Welcome to NewsBreak, an open platform where diverse perspectives converge. Most of our content comes from established publications and journalists, as well as from our extensive network of tens of thousands of creators who contribute to our platform. We empower individuals to share insightful viewpoints through short posts and comments.
Pattern of brain damage could be linked to military suicides
Over the last decade, more than a dozen Navy SEALs have taken their own lives, often displaying mysterious and uncharacteristic behaviors before their deaths. The common explanation for doctors had long been post-traumatic stress disorder. But with recent inspections of their brains postmortem, a pattern of tissue damage has been uncovered — resulting not from high-grade explosives or enemy bombardment but from repeatedly firing their own weapons.
North Koreans wear Kim Jong Un pins as the supreme leader builds godlike personality Original
Pins depicting Supreme Leader Kim Jong Un have reportedly been spotted on the lapels of North Korean officials, echoing the maneuvers taken by Kim’s father and grandfather in creating their cults of personality. In photos released Sunday by state media, Workers’ Party officials attending the 10th Plenary Meeting of the 8th Central Committee can be seen wearing Kim’s likeness across their hearts.
FCC prepares to cut ‘exorbitantly’ high fees for prison calls
For years, prisoners and their families have been charged staggeringly high rates for phone calls behind bars. Now, the Federal Communications Commission is seeking reform as early as July 18.
Ferrari races into new territory with line of $500,000 electric cars
Despite a resurgence of gas-powered cars, Ferrari, the Italian luxury car brand, plans to release its first electric vehicle, valued at a staggering $500,000. The car company, known for its exclusivity, will double down on its famously high price tags and bet on the pockets of the ultrawealthy while others have begun lowering their prices, according to Reuters.
South Korea says it will 'reconsider' providing weapons to Ukraine Original
South Korea has begun to rethink its policy on providing weapons to Ukraine as a concrete partnership grows between Russia and North Korea. In a statement from Seoul, the government plans to “reconsider” a long-standing principle that bars the sale of weapons to countries in the middle of conflict.
China renames hundreds of Uyghur villages with communist language
The People’s Republic of China has erased a number of village names that are culturally significant to the Uyghur people, replacing them with communist language, according to a report from the Human Rights Watch. The names of about 630 villages in the province of Xinjiang have been stripped of any references to Islam or uniquely Uyghur culture. Instead they have been secularized into Mandarin and replaced with terminology that is ideologically consistent with the PRC.
Sixteen missing soldiers from World War II and Korean War have been accounted for
Sixteen previously missing soldiers were accounted for Monday, according to the Defense POW/MIA Accounting Agency. Of the group, seven had been prisoners of war, held by the Japanese during World War II, while the remaining nine were killed in action in the Korean War. When the Japanese invaded the Philippine Islands one day after Pearl Harbor, thousands of Americans and Filipinos were captured as prisoners of war. Sgts. Jack H. Hohlfeld, Charles E. Young Jr., and Sam A.
Alleged lookout in prison killing of James ‘Whitey’ Bulger leaves court a free man Original
Sean McKinnon, the accused co-conspirator in the bludgeoning death of Boston gangster James “Whitey” Bulger, was sentenced to time served on Monday, avoiding any additional prison time. McKinnon, 38, pled guilty to the lesser charge of lying to a federal officer, with prosecutors dropping the most serious charge of conspiracy to commit first-degree murder.
Wreck of Sir Ernest Shackleton’s last ship found off coast of Canada
After 62 years of searching, the ship that led Sir Ernest Shackleton on his final voyage has been found. Using sonar equipment, a team led by the Royal Canadian Geographical Society discovered the schooner-rigged steamship Quest, 1,279 feet beneath the Labrador Sea. For decades, the location of the wreck had been unknown. It was last seen in the spring of 1962 when the ship struck an iceberg.
Who is Ben Carson? Meet one of the top names on Trump's VP shortlist Original
Former President Donald Trump is considering picking Dr. Ben Carson to be his running mate. The two have grown closer in the last decade, going from competing candidates in the 2016 Republican presidential primary to Carson serving as secretary of Housing and Urban Development during the Trump administration. Carson was born on Sept. 18, 1951. He is 72 years old. Carson grew up in Southwest Detroit. He lived in Vienna, Virginia, a suburb of Washington, until 2020 and has a home in Palm Beach, Florida.
Who is Doug Burgum? Meet Trump's Potential VP
Doug Burgum, the 33rd governor of North Dakota, has emerged from being a long-shot challenger to sitting at the top of a short list of possible running mates for Donald Trump. Burgum has presented himself as a businessman with a strong showing of loyalty to the former president. With an official announcement expected for July’s Republican National Convention, the Trump campaign has requested vetting materials from a short list of vice presidential contenders, including Burgum.
Meet the eight top names on Trump’s VP short list
Former President Donald Trump has kept the contest for his running mate open, and his preferences have largely remained secret. Throughout the 2024 cycle, Trump has relied on a number of surrogates to drum up support for him when he couldn't be there shaking hands himself. And when he was stuck in a courtroom in New York during his historic hush money trial, most of the people rumored to be on his short list made their way to the courthouse to show support for him.
Wreck of Sir Ernest Shackleton’s last ship found off coast of Canada
After 62 years of searching, the ship that led Sir Ernest Shackleton on his final voyage has been found. Using sonar equipment, a team led by the Royal Canadian Geographical Society discovered the schooner-rigged steamship Quest, 1,279 feet beneath the Labrador Sea. For decades, the location of the wreck had been unknown. It was last seen in the spring of 1962 when the ship struck an iceberg.
Have aliens been on Earth all along? Harvard researchers seem to think so Original
Instead of some far-off galaxy, a new paper suggests extraterrestrial life might come from underground.
Suspected Gilgo Beach serial killer charged with two additional murders
Rex Heuermann, the once successful Manhattan architect suspected of being the “Gilgo Beach Killer,” has been indicted with the killings of two additional women. In Suffolk County Superior Court, Heuermann was charged with the second-degree murders of Jessica Taylor and Sandra Costilla, raising the number of his alleged victims to at least six.
Suspect in Gilgo Beach serial killings charged with two additional murders
Rex Heuermann, the once successful Manhattan architect suspected of being the “Gilgo Beach Killer,” has been indicted with the killings of two additional women. In Suffolk County Superior Court, Heuermann was charged with the second-degree murders of Jessica Taylor and Sandra Costilla, raising the number of his alleged victims to at least six.
Ash Wednesday 1983
The memorial to firefighters who lost their lives on Ash Wednesday. Picture: PETER MCHUGH. By Peter McHugh On 16 February 1983, at 3.24pm, a bushfire started on Birds Land near Mount Morton Road at Belgrave Heights. The temperature at 2 pm was 40.5 degrees. The relative humidity was 14 per cent with wind from the north at 25 km an hour. The fine fuel moisture content at Kallista was estimated to be an extremely low 9 per cent and the Drought Index was 383.
Capacity to support predators scales with habitat size
Habitat reduction could drive biodiversity loss if the capacity of food webs to support predators is undermined by habitat-size constraints on predator body size.
Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes
Flap endonuclease 1 (FEN1) is a structure selective endonuclease required for proficient DNA replication and the repair of DNA damage. Cellularly active inhibitors of this enzyme have previously been shown to induce a DNA damage response and, ultimately, cell death.
#con15 Demob Dave.... What can it all mean?
The Tory Party conference gave a standing ovation to equality today as four days in Manchester finally took their toll. Hallucinogenic drugs and Boddingtons best bitter were being blamed as the nasty party emerged, blinking, into the 20th century - plans still on hold for the 21st. The shock move came during an appearance in front of the faithful of their present hero, and Prime Minister, David Cameron.
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