Peter Oluoch

1 Introduction T cells are major players in the adaptive immune response that recognize peptide antigens presented on the surface of cells by major histocompatibility complexes (MHCs), with CD4 T cells recognizing antigens presented by class II MHC (MHC-II) and CD8 T cells recognizing peptides presented by class I MHC (MHC-I). The recognition is mediated by the T-cell receptor (TCR), a heterodimer expressed on the surface of T cells.

Abstract Successful tuberculosis therapy requires treatment with an unwieldy multidrug combination for several months. Thus, there is a growing need to identify novel genetic vulnerabilities that can be leveraged to develop new, more effective antitubercular drugs. Consequently, recent efforts to optimize TB therapy have exploited Mtb chemical genetics to identify pathways influencing antibiotic efficacy, novel mechanisms of antibiotic action, and new targets for TB drug discovery.

Open AccessArticle by Peter O. Oluoch 1,2, Catherine S. Forconi 1, Cliff I. Oduor 2,3, Dominic A. Ritacco 1, Hoseah M. Akala 2, Jeffrey A. Bailey 3, Jonathan J. Juliano 4,5, John M. Ong’echa 2, Christian Münz 6 and Ann M.