Peter Pfeiffer

Sometimes, looking at how things started offers ideas for how its future will play out. The hallowed US Federal energy conservation program, known as Energy Star, has been in the news lately. It is being attacked, falling victim to the label of being an outdated government program that is no longer relevant. How did this happen? Where did it come from anyway? Let’s discuss its roots and see what that has to do with the present-day green or sustainability movement.

Abstract Systemic ALys amyloidosis is a debilitating protein misfolding disease that arises from the formation of amyloid fibrils from C-type lysozyme. We here present a 2.8 Å cryo-electron microscopy structure of an amyloid fibril, which was isolated from the abdominal fat tissue of a patient who expressed the D87G variant of human lysozyme. We find that the fibril possesses a stable core that is formed by all 130 residues of the fibril precursor protein.

Abstract Systemic AL amyloidosis is one of the most frequently diagnosed forms of systemic amyloidosis. It arises from mutational changes in immunoglobulin light chains. To explore whether these mutations may affect the structure of the formed fibrils, we determine and compare the fibril structures from several patients with cardiac AL amyloidosis.