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Peter Sims

As seen in: CNN, Forge, Medium, HuffPost, Nature, The Wall Street Journal, Fast Company, Genome Biology, Genome Medicine, Cell Press and
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Articles

Glioma-intrinsic MAPK/ERK signaling promotes immunotherapy efficacy through T cell infiltration and interferon responses

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By Kwang-Soo Kim, Junyi Zhang, Víctor A. Arrieta, Crismita Dmello, Elena Grabis, Yahaya A. Yabo, Si Ran Wang, Karl Habashy, Joseph Duffy, Junfei Zhao, Andrew Gould Verified, Rishi Jain, Li Chen, Jian Hu, Irina V. Balyasnikova, Dhan Chand, Daniel F Levey, Peter Canoll, Wenting Zhao, Peter Sims, Raul Rabadan, Surya Pandey, Bin Zhang, Pouya Jamshidi, Catalina Lee-Chang, Dieter Henrik Heiland, Adam M. Sonabend
| Nature Verified
Abstract Glioblastoma (GBM) remains a formidable challenge in neuro-oncology, with immune checkpoint blockade (ICB) only showing efficacy in some patients, while the mechanisms governing therapeutic responsiveness are poorly defined. Although MAPK/ERK signaling correlates with survival following ICB, its causal role and mechanisms underlying tumor immunogenicity remain unclear.
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Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells

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By Peter A. Szabo, Péter Szabó, Hanna M Levitin, Siddhi Nargund, Thomas Connors, David Chen, Jenny Jin Verified, Puspa Thapa, Rebecca Guyer, Daniel Caron, Joshua Gray, Rei Matsumoto, Masaru Kubota, Maigan Brusko, Todd M. Brusko, Donna L Farber, Peter Sims
| Nature Verified
Abstract Early life is essential for establishing memory T cells, which rapidly populate mucosal sites during infancy, although these nascent memory T cells are less protective than their adult counterparts. Here we used single-cell RNA sequencing of resting and CD3+CD28 antibody-stimulated T cells from lymphoid and mucosal tissues of infant (2–9 months) and adult (40–63 years) organ donors to investigate age-dependent mechanisms for functional regulation of human memory T cells.
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Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age - Nature Immunology

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By Steven Wells, Daniel B Rainbow, Peter A. Szabo, Péter Szabó, Can Ergen, Daniel Caron, Ana Raquel Maceiras, David Chen Verified, Allon Wagner, Lorna B. Jarvis, Krishnaa T. Mahbubani, Laura Richardson, Chuan Xu, Sarah A Teichmann, Donna L Farber, Peter Sims, Joanne Jones, Kouresh Saeb-Parsy
| Nature Verified
Abstract The immune system comprises multiple cell lineages and subsets maintained in tissues throughout the lifespan, with unknown effects of tissue and age on immune cell function. Here we comprehensively profiled RNA and surface protein expression of over 1.25 million immune cells from blood and lymphoid and mucosal tissues from 24 organ donors aged 20–75 years.
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See all 29 licensed articles (30 Total)