Peter Sims
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Articles by Peter Sims
Organ-specific colonization and niche remodeling in a human tissue model of metastasis
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Metastatic tumor cells must undergo multifaceted adaptation to migrate to and colonize distant organ tissues. Preclinical xenograft models fail to fully replicate the human tissue niche to interrogate this process. Here, Chramiec et al.
Glioma-intrinsic MAPK/ERK signaling promotes immunotherapy efficacy through T cell infiltration and interferon responses
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Abstract Glioblastoma (GBM) remains a formidable challenge in neuro-oncology, with immune checkpoint blockade (ICB) only showing efficacy in some patients, while the mechanisms governing therapeutic responsiveness are poorly defined. Although MAPK/ERK signaling correlates with survival following ICB, its causal role and mechanisms underlying tumor immunogenicity remain unclear.
By Kwang-Soo Kim, Junyi Zhang, Víctor A. Arrieta, Crismita Dmello, Elena Grabis, Yahaya A. Yabo, Si Ran Wang, Karl Habashy, Joseph Duffy, Junfei Zhao, Andrew Gould Verified, Rishi Jain, Li Chen, Jian Hu, Irina V. Balyasnikova, Dhan Chand, Daniel F Levey, Peter Canoll, Wenting Zhao, Peter Sims, Raul Rabadan, Surya Pandey, Bin Zhang, Pouya Jamshidi, Catalina Lee-Chang, Dieter Henrik Heiland, Adam M. Sonabend
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Nature
Verified
Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells
Abstract Early life is essential for establishing memory T cells, which rapidly populate mucosal sites during infancy, although these nascent memory T cells are less protective than their adult counterparts. Here we used single-cell RNA sequencing of resting and CD3+CD28 antibody-stimulated T cells from lymphoid and mucosal tissues of infant (2–9 months) and adult (40–63 years) organ donors to investigate age-dependent mechanisms for functional regulation of human memory T cells.
Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age - Nature Immunology
Abstract The immune system comprises multiple cell lineages and subsets maintained in tissues throughout the lifespan, with unknown effects of tissue and age on immune cell function. Here we comprehensively profiled RNA and surface protein expression of over 1.25 million immune cells from blood and lymphoid and mucosal tissues from 24 organ donors aged 20–75 years.
The spatial landscape of glial pathology and T cell response in Parkinson’s disease substantia nigra - Nature Communications
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Abstract Parkinson’s Disease (PD) is an incurable neurodegenerative disease that causes movement disorders. Neurons in PD aggregate α-synuclein and are depleted from the substantia nigra (SN), which is a movement control hub. The presence of α-synuclein-reactive T cells in PD patient blood suggests a role for adaptive immunity in the pathogenesis of PD. However, the characteristics of this response within the brain are not well understood.
By Kelly Jakubiak, Adithya Kannan, JaeSeung Lee, Shailesh Kumar, David Chen Verified, Ashley S. Harms, David Sulzer, James Goldman Verified, Peter Sims
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Nature
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Glioma-induced alterations in excitatory neurons are reversed by mTOR inhibition
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Keywords glioma glioma microenvironment excitatory neurons mTOR inhibition glioma-associated neuronal alterations glioma-induced plasticity dendritic spines neuronal hyperexcitability brain tumors alterations in neuronal activity brain tumor microenvironment Get full text access Log in, subscribe or purchase for full access. References 1. Rudà, R. ∙ Bello, L. ∙ Duffau, H. ... Seizures in low-grade gliomas: natural history, pathogenesis, and outcome after treatments Neuro-Oncology. 2012; 14:iv55-iv64 2.
By Alexander R. Goldberg, Athanassios Dovas, Daniela Torres, Brianna Pereira, Ashwin Viswanathan, Sohani Das Sharma, Angeliki Mela, Edward M. Merricks, Cristina Megino-Luque, Julie J. McInvale, Markel Olabarria, Leila Abrishami Shokooh, Hanzhi T. Zhao, Cady Chen, Corina P. Kotidis, Matei A Banu, Aida Razavilar, Ankita Saxena, Cole Chokran, Nelson Humala, Weihao Xu, Jordan B. Metz, Eric A. Bushong, Daniela Boassa, Mark Ellisman, Elizabeth M.C. Hillman, Gunnar Hargus, Jose Javier Bravo-Cordero, Guy M. McKhann, Brian Gill, Steven Rosenfeld Verified, Catherine Schevon, Jeffrey Bruce, Peter Sims, Darcy S. Peterka, Peter Canoll, Peter Calvaresi, Tejaswi D. Sudhakar, Aayushi Mahajan
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Cell Press
Verified
A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states - Nature Neuroscience
Abstract Human microglia play a pivotal role in neurological diseases, but we still have an incomplete understanding of microglial heterogeneity, which limits the development of targeted therapies directly modulating their state or function. Here, we use single-cell RNA sequencing to profile 215,680 live human microglia from 74 donors across diverse neurological diseases and CNS regions.
Land: our most precious resource
Land is the single most vital resource for humans to live and prosper, but there is not enough useable land to fulfil everything that humans might wish to use it for. In the UK, to protect and restore biodiversity; be self-sufficient in food, energy, wood, and clothing, with the current national diet and levels of consumption; and reduce carbon emissions would take more land area than exists across our island. How should this be resolved?
A New Renaissance is Underway
Amanda Gorman’s call for light captured America. “For there is always light / If only we’re brave enough to see it/ If only we’re brave enough to be it.” It was just the right clarion call for the times, coming from a young woman whose artistry was deservedly supported with patronage. America needs a cultural rebirth and a new visionfor what is possible, not unlike how Europe needed a cultural “rinascità” (“rebirth”) to rise out of the stagnation of the Middle Ages.
Découvrir son leadership authentique
L'idée en bref LE CONSTAT Plus d’un millier d’études menées sur le leadership n’ont jamais réussi à dresser un portrait type du leader. Et c’est tant mieux. Car personne ne peut être authentique en essayant d’imiter quelqu’un. LA MÉTHODE Une équipe de recherche a interviewé 125 leaders pour répondre à la question : « Comment les individus peuvent-ils devenir et rester des leaders authentiques ?
I think, therefore I’m…screwed
Image: Pfizer Medical Team Why “Head-Driven” Leaders Are Struggling By Marco Annunziata & Peter Sims Do you feel a bit lost right now? Blindsided? This sudden pandemic has changed life virtually overnight, and what got us here won’t get us out of the situation we find ourselves in. This moment has undermined and derailed one of our most tried and trusted leadership styles: the “head-driven” leadership style that had become the dominant paradigm, heavily analytical and data-driven.
Elite Universities Are Breeding Grounds for Insecure Overachievers
Credit: David Madison/Getty Images In college, I dreamed about getting into Stanford Business School. That seemed like the ticket to a successful and good life. Then, in 2002, when the then dean of admissions called to tell me I had been admitted, I hung up and cried — it felt like the culmination of years of schooling and hard work, stress, and determination. If only true “success” were as simple as attaining big goals.
What Is Success?
The BLK SHP in Mexico City, May 2019 In college, I dreamed about getting into Stanford Business School. That seemed like the ticket to a successful and good life. Then, in 2002, when the then Dean of Admissions called to tell me I had been admitted, I hung up and cried — the culmination of years of schooling and hard work, stress, and determination. If only true “success” were as simple as attaining big goals.
Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease
Abstract Human T cells coordinate adaptive immunity in diverse anatomic compartments through production of cytokines and effector molecules, but it is unclear how tissue site influences T cell persistence and function. Here, we use single cell RNA-sequencing (scRNA-seq) to define the heterogeneity of human T cells isolated from lungs, lymph nodes, bone marrow and blood, and their functional responses following stimulation.
Dissecting lung development and fibrosis at single-cell resolution
Genome Medicine201911:33 https://doi.org/10.1186/s13073-019-0645-7 © The Author(s). 2019 Published: 24 May 2019 Editorial summary Single-cell transcriptome profiling has enabled high-resolution analysis of cellular populations in tissues during development, health, and disease. Recent studies make innovative use of single-cell RNA sequencing (scRNAseq) to investigate mechanisms that allow immune cells to interact with tissue components in the lung during development and fibrotic lung disease.
Critical Analysis of Particle Detection Artifacts in Synaptosome Flow Cytometry
Methods/New Tools, Novel Tools and Methods Benjamin D. Hobson and Peter A. Sims eNeuro 22 May 2019, ENEURO.0009-19.2019; DOI: https://doi.org/10.1523/ENEURO.0009-19.2019 Abstract Flow cytometry and fluorescence-activated sorting are powerful techniques that hold great promise for studying heterogeneous populations of submicron particles such as synaptosomes, but many technical challenges arise in these experiments.
Critical Analysis of Particle Detection Artifacts in Synaptosome Flow Cytometry
Research ArticleMethods/New Tools, Novel Tools and Methods Benjamin D. Hobson and Peter A. Sims eNeuro 22 May 2019, 6 (3) ENEURO.0009-19.2019; DOI: https://doi.org/10.1523/ENEURO.0009-19.2019 Abstract Flow cytometry and fluorescence-activated sorting are powerful techniques that hold great promise for studying heterogeneous populations of submicron particles such as synaptosomes, but many technical challenges arise in these experiments.
SCOPE-Seq: a scalable technology for linking live cell imaging and single-cell RNA sequencing
Genome Biology201819:227 https://doi.org/10.1186/s13059-018-1607-x © The Author(s). 2018 Received: 11 July 2018 Accepted: 6 December 2018 Published: 24 December 2018 Abstract Optically decodable beads link the identity of a sample to a measurement through an optical barcode, enabling libraries of biomolecules to be captured on beads in solution and decoded by fluorescence. This approach has been foundational to microarray, sequencing, and flow-based expression profiling technologies.
Why Fear of Failure is the No. 1 Enemy of Creativity | HBR Ascend
Never once in my life until my mid 30s did anyone ever (to the best of my recollection) call me “creative.” But now, I hear it all the time. Well, after a traditional education, business school, and five years working in strategy consulting and venture capital, I went to a cocktail reception at Stanford’s d.school, the Hasso Plattner Institute of Design, where I met George Kembel, cofounder and executive director of the school.
A Truthful Tale from the Entrepreneurs Journey
On Monday July 31st 2017, I hosted a tea party, marking the end of a chapter. Each invited guest brought their own favourite fine-boned china. I served tea at 3 pm in the retail space that was once my pride and joy, now naked as a newborn baby. Speaking of newborn babies… I birthed my ungrateful child in 2013 and named it The Tailor’s Daughter Inc.
The average American has only one close friend — here's how we got to this point
About a month ago, a group of about 20 men — all fathers in their 30s and 40s — gathered at a home in Oakland, California to talk fatherhood. Alarmingly, when asked how many of them had "real friends" — the kind of confidantes with whom they could talk honestly and vulnerably about life on a regular basis, through good times and bad — only two people raised their hands. It might be tempting to interpret this sense of isolation as a crisis of masculinity in the US.
OPINIÓN: La verdadera historia detrás de los problemas del CEO de Uber
Nota del editor: Peter Sims fue inversionista en capitales de riesgo. Es empresario y autor de los libros Little Bets y True North. Las opiniones en esta columna pertenecen exclusivamente al autor. (CNN) — Es triste decir que en el Silicon Valley de la actualidad, a nadie le sorprenden los acontecimientos recientes en Uber, entre ellos las acusaciones de acoso sexual o el video en el que se ve al cofundador y director ejecutivo de Uber reprendiendo a un conductor de la empresa.
The real story behind Uber CEO
Peter Sims is a former venture capital investor. He is an entrepreneur and the author of "Little Bets" and "True North." The views expressed in this commentary are solely those of the author. (CNN) It's a sad statement about Silicon Valley today that virtually no one there is surprised about the latest developments at Uber, including allegations of sexual harassment , or a video of the co-founder and CEO berating an Uber driver .
How the Rust Belt is keeping the American dream alive
Peter Sims is the founder and CEO of Parliament Inc., the author of "Little Bets" and "True North," a social entrepreneur and angel investor for the BLK SHP. The views expressed in this commentary are those of the author. (CNN) I get it if you think the American dream is dead. I grew up in Trump country, so I have definitely heard it before. Anyone who studies economic mobility will cite it as empirical fact.
Pixar's Motto: Going From Suck to Nonsuck
In a world that is obsessed with preventing errors and perfection, perhaps it's ironic that despite 11 straight blockbuster movies, Pixar cofounder and President Ed Catmull describes Pixar's creative process as "going from suck to nonsuck." That's because Catmull and Pixar's directors think it's better to fix problems than to prevent errors.
Think, Act and Let Go
Peter E. Greulich is an author, publisher and public speaker. His forthcoming book due in the 1st Quarter of 2017, Think Again: How Maximizing Shareholder Value Failed IBM, studies how a corporation can truly maximize shareholder value. IBM’s history reflects an almost non-intuitive truth: that a corporation maximizes shareholder value by maximizing stakeholder value.
Putting The Shit Back In Get Shit Done
If you work in the startup or tech world, you’re probably familiar with the phrase, “Get S*&t Done” or its more PG-rated cousin, “Get Stuff Done”. Both are used as refrains for a focus on driving results and as hiring filters to rule out folks who want to consult on a business rather than roll up their sleeves and do the hard work.
The Montessori Mafia
It may seem like a laughable “only in New York” story that Manhattan mother, Nicole Imprescia, is suing her 4-year-old daughter’s untraditional private preschool for failing to prepare her for a private school admissions exam. But her daughter’s future and ours might be much brighter with a little less conditioning to perform well on tests and more encouragement to discover as they teach in Montessori schools.
Silicon Valley Needs a MAYOR
Yesterday, seated in an office just off El Camino Real in Menlo Park, I had an interesting visit with Dr. Richard Moran, President of Menlo College. There in the heart of Silicon Valley, we discussed some of the latest including the migration of talent and companies North, to San Francisco, venture capital inflows and outflows (we’re both former VC investors), and then we got to Silicon Valley’s ethics these days. The phrase immediately struck a deep nerve.
The Return of the Guild
It’s easy to forget that guilds once ruled the world. By the time Rembrandt painted his masterpiece “Syndics of the Drapers’ Guild” in 1662, the concept, and inherent intrinsic value of guilds, was already a 400 year-old idea. If you were a craftsman, or merchant, or clothier in the case of Rembrandt’s drapers, guilds offered members and society at large great benefits: ranging from education and apprenticeships to medieval forms of peer review, and all important stamps of approval.
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