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Pharmacokinetics Unit

As seen in: European Journal of Cancer
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Articles

Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients

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By Pharmacokinetics Unit, Luis Quintairos, Helena Colom, Olga Millán
| PLOS
Loading metrics Open Access Peer-reviewed Research Article Luis Quintairos , Helena Colom , Olga Millán, Virginia Fortuna, Cristina Espinosa, Lluis Guirado, Klemens Budde, Claudia Sommerer, Ana Lizana, Yolanda López-Púa, Mercè Brunet Luis Quintairos, Helena Colom, Olga Millán, Virginia Fortuna, Cristina Espinosa, Lluis Guirado, Klemens Budde, Claudia Sommerer, Ana Lizana, Yolanda López-Púa Published: January 22, 2021 https://doi.org/10.1371/journal.pone.0245880 Figures Abstract Previous...
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Clinical development of cell therapies for cancer: The regulators' perspective

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By Biotechnology Unit, Khadija Rantell, Andrew R. Exley, Pharmacokinetics Unit
| European Journal of Cancer
Highlights • Discussion between regulator and developer may bring products to patients sooner. • How to establish a benefit-risk profile is one focus for such discussions. • Choice of comparator and duration of benefit are also key. • Early approval implies that more data are needed in the post-approval setting. Abstract Novel cell therapies for haematological malignancies and solid tumours address pressing clinical need while offering potentially paradigm shifts in efficacy.
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