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Combination therapy with broadly neutralizing antibodies, antiretroviral therapy and CCR5 blockade limits viral reservoir seeding in infant macaque model of HIV
Abstract Lack of access to antiretroviral therapy (ART) leads to the transmission of human immunodeficiency virus in ~120,000 children annually, emphasizing the need for new strategies to prevent lifelong infection. Here in an infant rhesus macaque model of peripartum oral infection, we show that broadly neutralizing antibodies directed to the viral envelope protein were insufficient to prevent latent reservoir establishment, independent of daily ART.
Virus Control in Vaccinated Rhesus Macaques Is Associated with Neutralizing and Capturing Antibodies against the SHIV Challenge Virus but Not with V1V2 Vaccine-Induced Anti-V2 Antibodies Alone | The Journal of Immunology
Ann J. Hessell, Liuzhe Li, Delphine C. Malherbe, Philip Barnette, Shilpi Pandey, William Sutton, David Spencer, Xiao-Hong Wang, Johannes S. Gach, Ruth Hunegnaw, Michael Tuen, Xunqing Jiang, Christina C. Luo, Celia C. LaBranche, Yongzhao Shao, David C. Montefiori, Donald N. Forthal, Ralf Duerr, Marjorie Robert-Guroff, Nancy L. Haigwood and Miroslaw K.
Virus Control in Vaccinated Rhesus Macaques Is Associated with Neutralizing and Capturing Antibodies against the SHIV Challenge Virus but Not with V1V2 Vaccine-Induced Anti-V2 Antibodies Alone | The Journal of Immunology
Ann J. Hessell, Liuzhe Li, Delphine C. Malherbe, Philip Barnette, Shilpi Pandey, William Sutton, David Spencer, Xiao-Hong Wang, Johannes S. Gach, Ruth Hunegnaw, Michael Tuen, Xunqing Jiang, Christina C. Luo, Celia C. LaBranche, Yongzhao Shao, David C. Montefiori, Donald N. Forthal, Ralf Duerr, Marjorie Robert-Guroff, Nancy L. Haigwood and Miroslaw K.
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