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Sohita Ojha

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Combination therapy with broadly neutralizing antibodies, antiretroviral therapy and CCR5 blockade limits viral reservoir seeding in infant macaque model of HIV

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By Jonah B. Sacha, Tracy Ordonez, Shilpi Pandey, Gabriela M. Webb, Philip Barnette, Cleiton T. Pessoa, Matthew C. Humkey, Jason Reed, Jodie Usachenko, Anne Lewis, Gabrielle Pastenkos, Bella Swan, Rachele M. Bochart, John R. Mascola, Amarendra Pegu, Emily J. Fray, Rachael M. Wolters, Janet D. Siliciano, Robert F. Siliciano, Scott Hansen, Koen K. A. Van Rompay, Ann J. Hessell, Nancy L. Haigwood, Anden Morehead, Shrivaas Vijayan, Altair Fazio, Heather Sidener, Sohita Ojha, Aaron Barber-Axthelm
| Nature Verified
Abstract Lack of access to antiretroviral therapy (ART) leads to the transmission of human immunodeficiency virus in ~120,000 children annually, emphasizing the need for new strategies to prevent lifelong infection. Here in an infant rhesus macaque model of peripartum oral infection, we show that broadly neutralizing antibodies directed to the viral envelope protein were insufficient to prevent latent reservoir establishment, independent of daily ART.
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