Philip Ruzycki
St. Louis
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Articles by Philip Ruzycki
The baseline vitreous proteome in rhegmatogenous retinal detachment: a case–control study of proliferative vitreoretinopathy
Abstract Proliferative vitreoretinopathy (PVR) is the leading cause of failure after rhegmatogenous retinal detachment (RRD) repair, yet no baseline biomarkers exist to stratify risk. In this retrospective, nested case–control study we asked whether the vitreous proteome at the time of primary RRD repair predicts subsequent PVR.
A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina
Keywords CRISPR screen retinitis pigmentosa neuroprotection gene therapy human retinal explants Get full text access Log in, subscribe or purchase for full access. References 1. Chaumet-Riffaud, A.E. ∙ Chaumet-Riffaud, P. ∙ Cariou, A. ... Impact of Retinitis Pigmentosa on Quality of Life, Mental Health, and Employment Among Young Adults Am. J. Ophthalmol. 2017; 177:169-174 2. Sahel, J.A. ∙ Marazova, K. ∙ Audo, I.
Molecular mechanism establishing the OFF pathway in vision - Nature Communications
Abstract Parallel ON and OFF (positive- and negative-contrast) pathways fundamental to vision arise at the complex synapse of cone photoreceptors. Cone pedicles form spatially segregated functionally opposite connections with ON and OFF bipolar cells. Here, we discover that mammalian cones express LRFN2, a cell-adhesion molecule, which localizes to the pedicle base.
A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens
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Catalytic isoforms of AMP-activated protein kinase differentially regulate IMPDH activity and photoreceptor neuron function
ResearchMetabolismOphthalmology Open Access | 10.1172/jci.insight.173707 JCI Insight. https://doi.org/10.1172/jci.insight.173707. Copyright © 2024, Lee et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract AMP-activated protein kinase (AMPK) plays a crucial role in maintaining ATP homeostasis in photoreceptor neurons.
Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms
eLife assessment This manuscript will be of interest to readers in the field of neural development and neurodegeneration. The study is important as it examines two disease-causing mutations within the homeodomain transcription factor Cone-Rod Homeobox (CRX) that causes retinopathy in humans. The data are solid, and the work contributes to our understanding of the underlying pathogenetic mechanisms.
Cell-specific systemic immune signatures associated with treatment burden in neovascular age-related macular degeneration
ABSTRACT Chroroidal neovascularization (CNV) accounts for the majority of severe vision loss in neovascular age-related macular degeneration (AMD). Despite therapies that target vascular endothelial growth factor (VEGF), patients are often under-responsive, require frequent eye injections to control disease, and eventually lose some vision despite chronic therapy implicating a multifactorial etiology in treatment response.
Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms
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MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity
To determine spatial and temporal patterns of Mll1 expression in the mouse retina, we analyzed Mll1 transcript levels and distribution during development. Quantitative real-time PCR (qRT-PCR) assays with Mll1-specific “Primer Set 1” (Fig. 1A, Supplementary Table S1) showed that Mll1 expression was constant from Postnatal day 0 (P0) to P5, but significantly increased in the second postnatal week (Fig. 1B), the crucial period for terminal differentiation of retinal neurons.
Multiple Isoforms of Nesprin1 Are Integral Components of Ciliary Rootlets
Publication HistoryPublished: June 15, 2017Accepted: May 19, 2017; Received in revised form: April 10, 2017; Received: December 12, 2016;
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