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Phuc Pham on Muck Rack

Phuc Pham

As seen in: Nature, WIRED Magazine, MDPI, ACS Publications, BioRxiv, The Nation, Wired Japan, Nguoi Viet Daily News
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Articles

LINKER: L earning In teractions between Functional Groups and Residues with Chemical K nowledge- E nhanced R easoning and Explainability Click to copy article link Article link copied!

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By Phuc Pham, Kevin Song, Jake Chen
| ACS Publications
1. Introduction Click to copy section linkSection link copied! Protein–ligand interactions underpin virtually all processes in chemical biology and pharmacology. Understanding how a ligand engages with its target protein, particularly which functional groups form what types of interactions with specific residues, is critical for elucidating molecular recognition mechanisms, rationalizing structure–activity relationships, and guiding lead optimization in drug discovery.
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Enabling multi-target drug discovery through latent evolutionary optimization and synthesis-aware prioritization (EVOSYNTH) - Communications Chemistry

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By Phuc Pham, Truong-Son Hy
| Nature Verified
Abstract Complex diseases, such as cancer and neurodegeneration, feature interconnected pathways, making single-target therapies ineffective due to pathway redundancy and compensatory mechanisms. Polypharmacy, which combines multiple drugs to target distinct proteins, addresses this but often leads to drug-drug interactions, cumulative toxicity, and complex pharmacokinetics.
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LANTERN: Leveraging Large Language Models and Transformers for Enhanced Molecular Interactions

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By Phuc Pham, Truong Son Hy, Cong Nga Ha
| BioRxiv
Abstract Understanding molecular interactions such as Drug-Target Interaction (DTI), Protein-Protein Interaction (PPI), and Drug-Drug Interaction (DDI) is critical for advancing drug discovery and systems biology. However, existing methods often struggle with scalability due to the vast chemical and biological space and suffer from limited accuracy when capturing intricate biochemical relationships.
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