Pianpian Zhao

Limited evidence suggests that osteoporosis might exacerbate depressive symptoms, while more studies show that depression negatively affects bone density and increases fracture risk. However, the Mendelian randomisation approach using the genome-wide association study summary data reported that genetic predisposition towards depression had no casual association with bone mineral density and fracture.

eLife assessment This study aims to explore the diabetes-bone paradox using the Mendelian Randomization approach. That diabetes itself is not the direct cause, but rather the complications or associated risk factors increase the risk of fracture, constitutes a valuable insight.