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Multimodal Metabolomics Analysis Reveals That Classic Decoction Mitigates Myocardial Ischemia‐Induced Damage by Modulating Energy and Branched‐Chain Amino Acid Metabolism
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description BMC_6081-sup-0001-SupportingInformation.docxWord 2007 document , 929.3 KB Figure S1 Total ion chromatograms of Gualou-Xiebai-Banxia Decoction by using UPLC-Q-TOF/MS under negative mode Figure S2. Ratio of infarct area to whole section in different groups. ## indicated p < 0.05 compared with sham group; ** indicated p < 0.05 compared with model group. Figure S3.
Shared genetic architecture highlights the bidirectional association between major depressive disorder and fracture risk
Limited evidence suggests that osteoporosis might exacerbate depressive symptoms, while more studies show that depression negatively affects bone density and increases fracture risk. However, the Mendelian randomisation approach using the genome-wide association study summary data reported that genetic predisposition towards depression had no casual association with bone mineral density and fracture.
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