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Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection
Keywords sensory neurons immune response HSV-1 skin dorsal root ganglia substance P MRGPRA1 TAFA4 neutrophils myeloperoxidase Introduction Host resistance to infection is primarily achieved through pathogen control and elimination, yet immune responses can also incur significant costs to tissue integrity and host fitness. Additional defense mechanisms are therefore necessary to limit this cost.
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