Ping Yin
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Cryo-EM structures of monomeric and dimeric human SAM complexes
Dear Editor, Mitochondrial β-barrel proteins, including translocase of the outer mitochondrial membrane 40 (TOM40), voltage-dependent anion channels (VDACs), and sorting and assembly machinery 50 (SAM50), mediate protein translocation and metabolite exchange across the outer mitochondrial membrane.1 Their biogenesis is mediated by the SAM, whose Omp85-family core subunit SAM50 contains a lateral gate implicated in substrate folding and membrane insertion.2,3,4 Studies of bacterial and...
Outcome observability in evidence on proton pump inhibitor-associated clostridioides difficile outcomes: a result-specific methodological audit
Abstract Objectives: Evidence on proton pump inhibitor (PPI) exposure and Clostridioides difficile infection (CDI) remains difficult to interpret because published estimates arise from heterogeneous target outcomes, risk sets, exposure contrasts, time structures, and ascertainment procedures. We evaluated whether a result-specific outcome-observability framework could make these differences explicit without using effect direction or statistical significance as classification criteria.
Targeting SYK enhances responses to radiotherapy and PD-1 blockade with myeloid immune remodeling in breast cancer
Abstract Introduction: Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase involved in immune signaling and has been implicated in tumor-intrinsic resistance to DNA-damaging therapies. Although SYK activity has been associated with poor outcomes in triple-negative breast cancer (TNBC), its role in resistance to combined radiotherapy and immune checkpoint blockade remains unclear.
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