pinky sharma

CLINICAL QUESTION Do non-opioid pain medications offer adequate pain control compared to opioids, following rhinoplasty? BOTTOM LINE There was no difference between opioid and non-opioid pain medications in post-operative pain control after rhinoplasty, suggesting that non-opioid medications may offer adequate pain control in rhinoplasty.

CLINICAL QUESTION How might proposed Medicare coverage restrictions on botulinum toxin injections affect patients with hemifacial spasm, facial dystonia, and nonflaccid facial paralysis? BOTTOM LINE The proposed Medicare policy could restrict individualized botulinum toxin treatment by limiting reimbursable injection sites and initial dosing.

CLINICAL QUESTION Can intracochlear DB-OTO gene therapy restore natural acoustic hearing in children with profound congenital deafness caused by biallelic OTOF variants? BOTTOM LINE In this first-in-human, open-label study, DB-OTO improved hearing in most children with OTOF-related deafness. At 24 weeks, nine of 12 participants met the primary efficacy endpoint, six could hear soft speech without assistive devices, and three achieved average normal hearing sensitivity.