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This is the first trial reporting a head-to-head comparison between Pmab-FOLFOX4 and Pmab-FOLFIRI in a first-line mCRC setting. Both chemotherapy regimens have similar activity when used without biologicals [27][27]. Pmab improves outcomes when added to either FOLFOX [19][19] or FOLFIRI [[4], [20]], without compromising quality of life [28][28].
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