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P.J. Barnes

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Articles

Advances And Challenges in Immunosuppressive Antibody Drug Conjugates

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By P.J. Barnes
| ScienceDirect Verified
Section snippets Introduction: Antibody-drug conjugates (ADCs) emerged as a novel class of precision medicine following the approval of Mylotarg™ by the US Food and Drug Administration in 2000 for treating acute myeloid leukemia [1]. This groundbreaking approval paved the way for the development of ADCs in oncology and beyond.
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Development of a free cytokine immunoassay to maintain binding and dissociation equilibrium in vitro

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By J. Massague, P.J. Barnes, J.J. O'Shea
| ScienceDirect Verified
Cytokines are small soluble proteins with a molecular weight ranging from 6 to 70 kDa. They are secreted by various cells, including lymphocytes, macrophages, natural killer cells (NK), mast cells, and stromal cells. Cytokines are crucial in regulating the immune system by dynamically controlling the growth, differentiation, and responsiveness of immune cells [1], [2], [3].
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