Pranathi Prasad on Muck Rack

Pranathi Prasad

As seen in: Cell Press
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Articles

Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis

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By Bongsoo Park, Alexandra M. Nicaise, Dimitrios Tsitsipatis, Liviu Pirvan, Daniel Zucha, Andi Munteanu, Pranathi Prasad, Cristian Bulgaru, Rafael Kollyfas, Julia Whitten, Cory M. Willis, Luka Culig, Joseph Llewellyn, Rosana-Bristena Ionescu, Jinshui Fan, Supriyo De, Matthew Ellis, Angeliki Spathopoulou, Luca Peruzzotti-Jametti, Tommaso Leonardi, Gabriel Balmus, Frank Edenhofer, Myriam Gorospe, Lukas Valihrach, Irina Mohorianu, Stefano Pluchino, Isabel Beerman, Magdy Mekdad, Madalena B.C. Simões-Abade, Grzegorz Krzak, Marta Suarez Cubero
| Cell Press Verified
Keywords progressive multiple sclerosis radial glia-like cells interferon response epigenetic dysregulation transcriptomic signatures single-cell multi-omics spatial transcriptomics neural stem cells cellular senescence neurodegeneration Introduction Multiple sclerosis (MS) is a complex neuroinflammatory and neurodegenerative disease characterized by inflammation and demyelination in the central nervous system (CNS).
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Oligodendroglia-to-neuron material transfer lights up the mouse CNS

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By Stefano Pluchino, de Faria, Pranathi Prasad
| rupress.org
Intercellular material transfer in the central nervous system (CNS) supports neuronal survival and activity. Mayrhofer et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20221632) characterize extensive regionally coordinated transfer of oligodendroglial ribosomal and nuclear material toward neurons, linked to satellite oligodendrocyte–neuron pairs in the mouse CNS.
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