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Praneet Veerapaneni

As seen in: Nature, MDPI, BioRxiv
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Articles

Soluble epoxide hydrolase in the liver orchestrates abdominal aortic aneurysm formation in mice - Communications Biology

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By David Kim, Tetsuo Horimatsu, Mourad Ogbi, Brandee Goo, Praneet Veerapaneni, Mary Moses, Stephen Cave, Tyler Benson, Hunter Sellers, Mitchell Shivers, Stephen B. Haigh, David Fulton, Gabor Csanyi, Yuqing Huo, Xiaochun Long, Philip Coffey, Richard Lee, Avirup Guha, Wenbo Zhi, Lufei Young, Darryl C. Zeldin, Sung Hee Hwang, Bruce D. Hammock, Neal L. Weintraub, Ronnie Chouhaita, Nicole Cyriac, Rosaria Prasad, Ragheb Harb, Ghaith Aboud
| Nature Verified
Abstract The liver plays an important role in cardiovascular disease by amplifying systemic inflammation, while the underlying mechanisms remain to be defined. Soluble epoxide hydrolase (sEH) is a pro-inflammatory enzyme, and pharmacological inhibition of sEH was shown to protect against various inflammatory diseases. In this study, we have identified a novel role of the liver, through expression of sEH, in the pathogenesis of abdominal aortic aneurysm (AAA).
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Transgenic Overexpression of HDAC9 Promotes Adipocyte Hypertrophy, Insulin Resistance and Hepatic Steatosis in Aging Mice

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By Michael Van Dyke, Praneet Veerapaneni, Brandee Goo, Samah Ahmadieh
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Integrative multiomics analysis of neointima proliferation in human saphenous vein: implications for bypass graft disease

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By David Kim, Brandee Goo, Philip Coffey, Praneet Veerapaneni
| BioRxiv
Abstract Introduction: Human saphenous veins (SV) are widely used as grafts in coronary artery bypass (CABG) surgery but often fail due to neointima proliferation (NP). NP involves complex interplay between vascular smooth muscle cells (VSMC) and fibroblasts. Little is known, however, regarding the transcriptomic and proteomic dynamics of NP. Here, we performed multi-omics analysis in an ex vivo tissue culture model of NP in human SV procured for CABG surgery.
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