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Soluble epoxide hydrolase in the liver orchestrates abdominal aortic aneurysm formation in mice - Communications Biology

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By David Kim, Tetsuo Horimatsu, Mourad Ogbi, Brandee Goo, Praneet Veerapaneni, Mary Moses, Stephen Cave, Tyler Benson, Hunter Sellers, Mitchell Shivers, Stephen B. Haigh, David Fulton, Gabor Csanyi, Yuqing Huo, Xiaochun Long, Philip Coffey, Richard Lee, Avirup Guha, Wenbo Zhi, Lufei Young, Darryl C. Zeldin, Sung Hee Hwang, Bruce D. Hammock, Neal L. Weintraub, Ronnie Chouhaita, Nicole Cyriac, Rosaria Prasad, Ragheb Harb, Ghaith Aboud
| Nature Verified
Abstract The liver plays an important role in cardiovascular disease by amplifying systemic inflammation, while the underlying mechanisms remain to be defined. Soluble epoxide hydrolase (sEH) is a pro-inflammatory enzyme, and pharmacological inhibition of sEH was shown to protect against various inflammatory diseases. In this study, we have identified a novel role of the liver, through expression of sEH, in the pathogenesis of abdominal aortic aneurysm (AAA).
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