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Prasanna Ekambaram

As seen in: Nature, BioRxiv
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Articles

MALT1 protease inhibition restrains glioblastoma progression by reversing tumor-associated macrophage-dependent immunosuppression in mice

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By Juliana Hofstatter Azambuja, Saigopalakrishna Yerneni, Lisa Maurer, Hannah E Crentsil, Linda R. Klei, Mei Smyers, Chaim Sneiderman, Kristina E Schwab, Rajesh Acharya, AiVi Nguyen, John Little IV, Jeffrey A Meridew, Yijen Wu, Prasanna Ekambaram, Dong Hu, John Bertin, Ari M Melnick, Gary Kohanbash, Riyue Bao, Peter Lucas, Linda M. McAllister-Lucas, Gabriela N. Debom, Josie L. Emery, Pete J. Gough
| Nature Verified
Abstract MALT1 protease is an intracellular signaling molecule that promotes tumor progression via cancer cell-intrinsic and cancer cell-extrinsic mechanisms. MALT1 has been mostly studied in lymphocytes, and little is known about its role in tumor-associated macrophages. We show that MALT1 is expressed in glioblastoma (GBM)-associated macrophages.
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CRISPRa-induced upregulation of human LAMA1 compensates for LAMA2-deficiency in Merosin-deficient congenital muscular dystrophy

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By Marie Johnson, Prasanna Ekambaram, Annie I Arockiaraj, Anushe Munir
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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The CARMA3-Bcl10-MALT1 Signalosome Drives NFκB Activation and Promotes Aggressiveness in Angiotensin II Receptor-Positive Breast Cancer

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By Prasanna Ekambaram, Nathaniel E. Hubel, Dong Hu, Saigopalakrishna Yerneni
| cancerres.aacrjournals.org
Tumor Biology and Immunology The CARMA3–Bcl10–MALT1 Signalosome Drives NFκB Activation and Promotes Aggressiveness in Angiotensin II Receptor–Positive Breast Cancer Prasanna Ekambaram, Jia-Ying (Lloyd) Lee, Nathaniel E. Hubel, Dong Hu, Saigopalakrishna Yerneni, Phil G. Campbell, Netanya Pollock, Linda R. Klei, Vincent J. Concel, Phillip C. Delekta, Arul M. Chinnaiyan, Scott A. Tomlins, Daniel R. Rhodes, Nolan Priedigkeit, Adrian V. Lee, Steffi Oesterreich, Linda M. McAllister-Lucas and Peter C. Lucas
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