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Pria G. Bose on Muck Rack

Pria G. Bose

As seen in: The Journal of Clinical Investigation
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Articles

T cell receptor signaling induces expression of lysine demethylase KDM6B to maintain Treg homeostasis

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By Minghong He, Beisi Xu, Pria G. Bose
| The Journal of Clinical Investigation
Abstract Tregs expressing forkhead box P3 (FOXP3) play crucial roles in maintaining immune tolerance and tissue integrity. EZH2, a histone H3 lysine 27 (H3K27) methyltransferase, is known as a key regulator of Treg identity and suppressive function upon activation. Here, we demonstrate that the H3K27 lysine demethylase KDM6B, which catalyzes the opposing reaction to EZH2, is also required for Treg identity and function after activation.
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