Prihardi Kahar

Submitted: 03 January 2026 You are already at the latest version 3-Amino-4-hydroxybenzoic acid (3,4-AHBA) is a non-proteinogenic aromatic compound that functions as a key biosynthetic precursor for diverse secondary metabolites with pharmaceutical and industrial value. Microbial production of 3,4-AHBA offers a sustain-able alternative to petroleum-based chemical synthesis; however, metabolic complexity and trade-offs between growth and product formation constrain rational strain design.

Submitted: 03 January 2026 You are already at the latest version Oleaginous yeasts are promising microbial platforms for lipid production from non-conventional carbon sources; however, acetate utilization is frequently constrained by physiological limitations associated with culture pH.

This version is not peer-reviewed. Dianti Rahmasari,Prihardi Kahar  *,Filemon Jalu Nusantara Putra,Chiaki Ogino Dianti Rahmasari,Prihardi Kahar  *,Filemon Jalu Nusantara Putra,Chiaki Ogino Submitted: 28 October 2025 You are already at the latest version This study investigates two genetically engineered Saccharomyces cerevisiae F118 strains, ΔCYB2::LpDLDH and ΔPDC1::LpDLDH, for D-LA (D-LA) production under high-glucose and inhibitor-stress conditions that mimic lignocellulosic hydrolysates.