Pritiranjan Sahoo on Muck Rack

Pritiranjan Sahoo

As seen in: Cell Reports, eLife
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Articles

ISGylation mechanism uncovers conformational specificity for HECT-family E3 ligase HERC5

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By Pritiranjan Sahoo, Dipti Ranjan Lenka, Atul Kumar, Gloria Grace Parmar, Mohini Sherawat, Bhagya Shri Trivedi
| Cell Reports Verified
Keywords ubiquitination, ISGylation, HECT, HERC5, ISG15, structural biology, biochemistry, biophysics Research topic(s) CP: molecular biology Introduction Type I interferons (IFNs-α/β) induce the expression of interferon-stimulated gene 15 (ISG15), a ubiquitin (Ub)-like modifier best known for its antiviral functions.1,2 Beyond its role in host defense, emerging evidence implicates ISG15 in diverse physiological processes, including DNA replication, bacterial infection responses, and the...
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Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans

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By Dipti Ranjan Lenka, Odetta Antico, Shakti Virendra Dahe, Pritiranjan Sahoo
| eLife
eLife assessment This is a useful manuscript describing the competitive binding between Parkin domains to define the importance of dimerization in the mechanism of Parkin regulation and catalytic activity.
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