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Puay Leng Lee

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Articles

Targeting P4HA1 promotes CD8+ T cell progenitor expansion toward immune memory and systemic anti-tumor immunity

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By Shijun Ma, Li-Teng Ong, Wee Chyan Lee, Henrik J. Ditzel, Yulan Wang, Qingfeng Chen, Wenyu Wang, Xiaojian Wu, Ern Yu Tan, Qiang Yu, Zemin Jiang, Puay Leng Lee, Mubaraka Yusuf
| Cell Press Verified
Keywords P4HA1 T cell memory T cell exhaustion mitochondria systemic immunity hypoxia PD-1 CAR T cells solid tumors cancer immunotherapy Get full text access Log in, subscribe or purchase for full access. References 1. Topalian, S.L. ∙ Drake, C.G. ∙ Pardoll, D.M. Immune checkpoint blockade: a common denominator approach to cancer therapy Cancer Cell. 2015; 27:450-461 2. Wherry, E.J. ∙ Kurachi, M. Molecular and cellular insights into T cell exhaustion Nat. Rev. Immunol. 2015; 15:486-499 3. Marcotte, R.
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