Pulavendran Sivasami on Muck Rack

Pulavendran Sivasami

As seen in: Wiley Online Library, Science Magazine, Cell Metabolism, Cell Press
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Articles

Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis

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By Cody Elkins, Chengyu Ye, Pulavendran Sivasami, Pamela P. Diaz-Saldana, Amy Peng, Miaoer Xu, Yeun-po Chiang, Samara B. Moll, Dormarie E. Rivera-Rodriguez, Luisa Cervantes-Barragan, Tuoqi Wu, Byron B. Au-Yeung, Christopher Scharer, Mandy L. Ford, Roy Mulpur
| Science Magazine Verified
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The use of human iPSC‐derived alveolar organoids to explore SARS‐CoV‐2 variant infections and host responses

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By Chaitanya Gandikota, Pulavendran Sivasami, Chaoqun Huang, Kishore Vaddadi
| Wiley Online Library Verified
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. Supporting Information Filename Description jmv29579-sup-0001-Supplementary_Figures_JMV_R1.pptx383.3 KB Supporting information. jmv29579-sup-0002-Supplementary_Table_1_JMV.xlsx29.6 KB Supporting information. jmv29579-sup-0003-Supplementary_Table_2_JMV.xlsx28.7 KB Supporting information. jmv29579-sup-0004-Supplementary_Table_3_JMV.docx17.4 KB Supporting information. REFERENCES 1 Tracking SARS-CoV-2 variants.
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Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity

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By Chaoran Li, Gang Wang, Pulavendran Sivasami, Ricardo Ramírez
| Cell Metabolism Verified
Highlights • Long-term, but not short-term, HFD feeding induces the loss of VAT-Tregs • Obesity reduces VAT-Treg Pparg transcripts while inducing IFN-response transcripts • Obesity-induced IFN-α, made by local pDCs, is directly toxic to VAT-Tregs • Blocking the pDC-IFNα axis restores VAT-Tregs and insulin sensitivity Summary The visceral adipose tissue (VAT) of lean mice hosts a unique population of regulatory T cells (Tregs) that have a distinct transcriptome and T cell receptor (TCR)...
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